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Recombinant Human CD44 protein (ab158063)

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SDS-PAGE - Recombinant Human CD44 protein (ab158063)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    製品の詳細

    • 製品名

      Recombinant Human CD44 protein
      CD44 タンパク質・ペプチド 製品一覧

    • 発現系

      Wheat germ

    • アクセッション番号

      P16070-4

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAA DLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAAN NTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNR DGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFST VHPIPDEDSPWITDSTDRIPATSTSSNTISAGWEPNEENEDERDRHLSFS GSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTR MTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTT EETATQKEQWFGNRWHEGYRQTPREDSHSTTGTAAASAHTSHPMQGRTTP SPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSTTLQPTANPNTGLVE DLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGG RRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGD SNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIR TPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVED RKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV

      • 領域

        1 to 699

      • タグ

        GST tag N-Terminus

    関連製品

    特性

    Our Abpromise guarantee covers the use of ab158063 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Western blot

      ELISA

    • 製品の状態

      Liquid

    • 備考

       

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • LHR
      • BA-1
      • CD 44
      • CD44
      • CD44 antigen
      • CD44 molecule
      • CD44 molecule (Indian blood group)
      • CD44_HUMAN
      • CDw44
      • CDW44 antigen
      • Cell surface glycoprotein CD44
      • chondroitin sulfate proteoglycan 8
      • CSPG8
      • ECMR-III
      • Epican
      • Extracellular matrix receptor III
      • GP90 lymphocyte homing/adhesion receptor
      • HCELL
      • hematopoietic cell E- and L-selectin ligand
      • Heparan sulfate proteoglycan
      • Hermes antigen
      • homing function and Indian blood group system
      • HSA
      • HUTCH-I
      • HUTCH1
      • HUTCHI
      • Hyaluronate receptor
      • IN
      • INLU-related p80 Glycoprotein
      • MC56
      • MDU2
      • MDU3
      • MGC10468
      • MIC4
      • MUTCH I
      • MUTCH1
      • PGP-1
      • PGP-I
      • PGP1
      • Phagocytic glycoprotein 1
      • Phagocytic glycoprotein I
      • Soluble CD44
      see all

    • 機能

      Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

    • 組織特異性

      Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

    • 配列類似性

      Contains 1 Link domain.

    • ドメイン

      The lectin-like LINK domain is responsible for hyaluronan binding.

    • 翻訳後修飾

      Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
      N-glycosylated.
      O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s).
      Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human CD44 protein (ab158063)
      SDS-PAGE - Recombinant Human CD44 protein (ab158063)
      ab158063 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab158063 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab158063 は論文での使用が確認できていません。

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