AB167826

Recombinant Human C1GALT1 protein

Name: Recombinant Human C1GALT1 protein (ab167826) | Abcam
Brand: Abcam Limited
SKU: AB167826
Price: 100000 JPY
Availability: InStock

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Recombinant Human C1GALT1 protein is a Human Fragment protein, in the 30 to 363 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, B3Gal-T8, Core 1 O-glycan T-synthase, C1GalT1, Core 1 beta3-Gal-T1, C1GALT1

1 Images

SDS-PAGE - Recombinant Human C1GALT1 protein (AB167826)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human C1GALT1 protein (AB167826)

15% SDS-PAGE analysis of ab167826 (3µg).

Key facts

精製度

>80% SDS-PAGE

発現系

Escherichia coli

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

アクセッション番号

Q9NS00

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSLLGEKVDTQPNVLHNDPHARHSDDNGQNHLEGQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLRWLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIEDLALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGCCSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKLGNP","proteinLength":"Fragment","predictedMolecularWeight":"41.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":363,"aminoAcidStart":30,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NS00","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

C1GALT1 also known as core 1 β13-galactosyltransferase is an enzyme important for the synthesis of core 1 O-glycans. The enzyme has a molecular mass of approximately 55 kDa. It localizes in the Golgi apparatus where it actively participates in glycosylation processes. C1GALT1 shows widespread expression in various tissues including the liver lungs and intestines. By catalyzing the transfer of galactose to N-acetylgalactosamine on proteins it plays an important role in O-glycan biosynthesis.

Biological function summary

The function of C1GALT1 extends to modifying proteins that impact cell-cell interactions protein stability and signaling pathways. C1GALT1 does not work alone but as a part of a complex with chaperone protein COSMC which is necessary for its glycosyltransferase activity. This complex formation is essential to ensure the proper structure and function of the resulting glycoproteins which have a broad range of impacts in cell biology and communication.

Pathways

C1GALT1 plays a significant role in the mucin-type O-glycan biosynthesis pathway which is critical for producing mucins. These proteins are important for protective mucus barriers in several organs. C1GALT1 shows interaction with galectin proteins that recognize specific glycan structures influencing cellular processes such as adhesion and migration. Additionally it participates in the PI3K-Akt signaling pathway which links to cell growth and survival often intersecting with pathways involving other glycosyltransferases.

C1GALT1 has associations with IgA nephropathy also known as Berger's disease where abnormal glycosylation patterns of IgA1 occur. This disorder often involves the misfunction of proteins like C1GALT1 and COSMC. Furthermore aberrant C1GALT1 activity may have links to cancer progression as improper glycosylation can impact tumor cell migration and invasion. C1GALT1's interplay with galectins and other glycoproteins influences these pathological conditions making it a focal point for understanding and potentially targeting these diseases.

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製品の性状

製品の状態

Liquid

補足情報

ab167826 was purified using conventional chromatography techniques.

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一般的な情報

機能

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed : 11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).

配列の類似性

Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information C1GALT1

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Abcam product promise

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Recombinant Human C1GALT1 protein