AB316065

Recombinant Human BPIFA1/LUNX protein

Name: Recombinant Human BPIFA1/LUNX protein (ab316065) | Abcam
Brand: Abcam Limited
SKU: AB316065
Price: 72000 JPY
Availability: InStock

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Recombinant Human BPIFA1/LUNX protein is a Human Fragment protein, in the 20 to 256 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level.

別名を表示する

LUNX, NASG, PLUNC, SPLUNC1, SPURT, UNQ787/PRO1606, BPIFA1, BPI fold-containing family A member 1, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Short PLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl

Key facts

精製度

>95% HPLC

エンドトキシンレベル

< 1 EU/µg

発現系

Escherichia coli

生物活性

アクセッション番号

Q9NP55

アニマルフリー

キャリアフリー

Yes

種

Human

バッファー組成

Constituents: PBS

storage-buffer

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配列情報

[{"sequence":"QFGGLPVPLDQTLPLNVNPALPLSPTGLAGSLTNALSNGLLSGGLLGILENLPLLDILKPGGGTSGGLLGGLLGKVTSVIPGLNNIIDIKVTDPQLLELGLVQSPDGHRLYVTIPLGIKLQVNTPLVGASLLRLAVKLDITAEILAVRDKQERIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVCPLVNEVLRGLDITLVHDIVNMLIHGLQFVIKV","proteinLength":"Fragment","predictedMolecularWeight":"24.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":256,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NP55","tags":[]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Palate Lung Nasal Epithelium Clone (PLUNC) also known as SPLUNC1 or BPI-fold containing family A member 1 is a protein involved in host defense mechanisms. It has a molecular mass of approximately 25 kDa. High expression levels are found in the upper respiratory tract where it plays a role in airway surface liquid homeostasis. You can also detect it in salivary glands and other mucosal surfaces. Its expression is linked to innate immunity providing a first line of defense.

Biological function summary

This protein functions to modulate the physical and chemical environment at mucosal surfaces. It helps maintain the integrity of epithelial barriers against pathogens. As part of no particular protein complex PLUNC acts as a surfactant with anti-microbial properties in respiratory tissues. It helps maintain the viscosity and hydration of airway secretions facilitating the trapping and clearance of inhaled pathogens and particles.

Pathways

PLUNC is implicated in innate immune responses and mucosal defense mechanisms. It interacts within pathways involving the regulation of inflammation and mucociliary clearance. Proteins related to PLUNC in these pathways include SBEM and the airway-specific secretory proteins. Through these interactions it helps the lungs manage both pathogen load and airway clearances such as mucociliary escalator actions necessary to protect the respiratory system.

PLUNC is related to cystic fibrosis and chronic rhinosinusitis. In cystic fibrosis its regulation affects mucus viscosity and bacterial colonization potentially worsening respiratory symptoms. In chronic rhinosinusitis altered expression of PLUNC links to inflammation and recurrent infections. It connects with CFTR protein in cystic fibrosis impacting ion transport and mucociliary function. Through these mechanisms PLUNC can play a significant role in the progression of specific airway-related conditions.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed : 25223608). Plays a role in the innate immune responses of the upper airways (PubMed : 23132494, PubMed : 23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed : 23132494, PubMed : 23499554, PubMed : 27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed : 24043776, PubMed : 24124190). Plays a role in the airway inflammatory response after exposure to irritants (PubMed : 11425234). May attract macrophages and neutrophils (PubMed : 23132494).

配列の類似性

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

翻訳後修飾

May be N-glycosylated.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information BPIFA1

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Recombinant Human BPIFA1/LUNX protein