AB235881

Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus)

Name: Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag) (ab235881)
Brand: Abcam Limited
SKU: AB235881
Price: 60000 JPY
Availability: InStock

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Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) is a Human Fragment protein, in the 33 to 293 aa range, expressed in Baculovirus infected insect cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal cell antigen 1, Cyclic ADP-ribose hydrolase 2, BST-1, cADPR hydrolase 2, BST1

1 Images

SDS-PAGE - Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) (AB235881)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) (AB235881)

15% SDS-PAGE analysis of 3 μg ab235881.

28-40 kDa (Under reducing conditions)

Key facts

精製度

>95% SDS-PAGE

Affinity purified

エンドトキシンレベル

< 0.1 EU/µg

発現系

Baculovirus infected insect cells

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q10588

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"linker":null,"sequence":"RWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"30.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":293,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q10588","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.

Biological function summary

BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.

Pathways

BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.

Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.

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一般的な情報

機能

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed : 7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).

配列の類似性

Belongs to the ADP-ribosyl cyclase family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information BST1

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Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus)