Recombinant human BMPR1A protein (ab105907)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 90% Densitometry
- Active: Yes
- Suitable for: WB, Functional Studies
製品の詳細
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製品名
Recombinant human BMPR1A protein
BMPR1A タンパク質・ペプチド 製品一覧 -
生理活性
The Specific activity of ab105907 was determined to be 1.2 nmol/min/mg.
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精製度
> 90 % Densitometry.
Purity was determined to be >90% by densitometry. Affinity purified. -
発現系
Baculovirus infected Sf9 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
予測される分子量
66 kDa including tags -
領域
187 to 532
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関連製品
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Substrate reagent
特性
Our Abpromise guarantee covers the use of ab105907 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Western blot
Functional Studies
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製品の状態
Liquid -
備考
ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- 10q23del
- Activin A receptor type II like kinase 3
- Activin receptor like kinase 3
see all -
機能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. -
組織特異性
Highly expressed in skeletal muscle. -
関連疾患
Juvenile polyposis syndrome
Polyposis syndrome, mixed hereditary 2
A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome. -
配列類似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
画像
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Functional Studies - Recombinant human BMPR1A protein (ab105907)The specific activity of BMPR1A (ab105907) was determined to be 1.4 nmol/min/mg as per activity assay protocol
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SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS PAGE analysis of ab105907 -
SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS PAGE analysis of ab105907 -
Functional Studies - Recombinant human BMPR1A protein (ab105907)Kinase Assay demonstrating specific activity of ab105907 at 1.2 nmol/min/mg. -
SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS-PAGE showing ab105907 at approximately 66kDa.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab105907 は論文での使用が確認できていません。