AB167840

Recombinant Human Bex1 protein

Name: Recombinant Human Bex1 protein (ab167840) | Abcam
Brand: Abcam Limited
SKU: AB167840
Price: 88000 JPY
Availability: InStock

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Recombinant Human Bex1 protein is a Human Full Length protein, in the 1 to 125 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

Protein BEX1, Brain-expressed X-linked protein 1, BEX1

1 Images

SDS-PAGE - Recombinant Human Bex1 protein (AB167840)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Bex1 protein (AB167840)

15% SDS-PAGE analysis of ab167840 (3 µg).

Key facts

精製度

>80% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

アクセッション番号

Q9HBH7

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP","proteinLength":"Full Length","predictedMolecularWeight":"17.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":125,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HBH7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Bex1 also known as Brain Expressed X-linked 1 is a protein primarily involved in cellular processes such as cell cycle regulation and apoptosis. It has a molecular mass of approximately 14 kDa. Bex1 shows expression mainly in the brain but it can also be found in other tissues such as the testis and liver. Its location and size suggest a highly specialized role in cellular signaling and function.

Biological function summary

Bex1 interacts with components of the signaling pathways to regulate neuronal differentiation and survival. It can form part of a protein complex that affects transcription factors leading to modifications in gene expression profiles. By influencing these activities Bex1 plays an important role in maintaining normal neurological function and development.

Pathways

The role of Bex1 integrates into neurotrophic signaling and MAP kinase pathways. This protein is linked with brain-derived neurotrophic factor (BDNF) signaling affecting neuronal growth and plasticity. Bex1 is also associated with mitogen-activated protein kinases (MAPKs) which are critical in processes such as synaptic transmission and neuronal differentiation. Through these pathways Bex1 maintains interactions with various proteins ensuring effective signal transduction in neural tissues.

Altered expression or mutations of Bex1 have been implicated in neurodegenerative diseases and certain cancers. In Alzheimer's disease Bex1's connection with BDNF signaling reveals its potential involvement in neurodegeneration and loss of cognitive function. Additionally its modulation of apoptosis pathways raises interest in studying Bex1 in brain cancers where it may affect tumor growth and resistance. In these contexts Bex1’s role in regulating critical proteins like BDNF highlights its importance in disease mechanisms.

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製品の性状

製品の状態

Liquid

補足情報

ab167840 was purified using conventional chromatography techniques.

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一般的な情報

機能

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex : associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).

配列の類似性

Belongs to the BEX family.

翻訳後修飾

Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome.. Ubiquitinated. Degraded by the proteasome.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information BEX1

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Abcam product promise

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Recombinant Human Bex1 protein