Recombinant human BAFF-R protein (ab157066)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 0.100 Eu/µg
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE
製品の詳細
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製品名
Recombinant human BAFF-R protein
BAFF-R タンパク質・ペプチド 製品一覧 -
生理活性
Inhibits rhsBAFF mediated splenocyte survival. -
精製度
> 95 % SDS-PAGE. -
エンドトキシン・レベル
< 0.100 Eu/µg -
発現系
HEK 293 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
RRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASSP APRTALQPQESVGAGAGEAA -
予測される分子量
40 kDa -
領域
2 to 71 -
配列の追加情報
The extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.
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特性
Our Abpromise guarantee covers the use of ab157066 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
SDS-PAGE
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製品の状態
Lyophilized -
備考
Binds human and mouse BAFF. Detection of membrane-bound human and mouse BAFF in combination with PAb to human IgG1. Inhibits rhsBAFF mediated splenocyte survival. -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. 1mg/ml (after reconstitution).
関連情報
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別名
- B cell activating factor receptor
- B-cell-activating factor receptor
- BAFF R
see all -
機能
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
組織特異性
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
関連疾患
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
配列類似性
Contains 1 TNFR-Cys repeat. -
細胞内局在
Membrane. - Information by UniProt
画像
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Functional Studies - Recombinant human BAFF-R protein (ab157066)ab157066 used to show rhBAFF-R:Fc inhibits rhsBAFF-mediated activation of freshly isolated mouse splenocytes.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab157066 は論文での使用が確認できていません。
