AB229361

Recombinant Human ART4/DOK1 protein (His tag C-Terminus)

Name: Recombinant Human ART4/DOK1 protein (His tag) (ab229361) | Abcam
Brand: Abcam Limited
SKU: AB229361
Price: 92000 JPY
Availability: InStock

Be the first to review this product! Submit a review

(0 Publication)

Recombinant Human ART4/DOK1 protein (His tag C-Terminus) is a Human Full Length protein, in the 47 to 285 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

CD297, DO, DOK1, ART4, Ecto-ADP-ribosyltransferase 4, ADP-ribosyltransferase C2 and C3 toxin-like 4, Dombrock blood group carrier molecule, Mono(ADP-ribosyl)transferase 4, NAD(P)(+)--arginine ADP-ribosyltransferase 4, ARTC4

1 Images

SDS-PAGE - Recombinant Human ART4/DOK1 protein (His tag) (AB229361)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ART4/DOK1 protein (His tag) (AB229361)

15% SDS-PAGE analysis of 3 μg ab229361.

MW 28-40 kDa (SDS-PAGE under reducing conditions).

Key facts

精製度

>85% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q93070

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

製品の詳細

This product was previously labelled as ART4

style

left-column

配列情報

[{"sequence":"ADPSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKAHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"28.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":285,"aminoAcidStart":47,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q93070","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

style

left-column

出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ART4 also known as CD297 and DOK1 play critical roles in cell signaling. ART4 belongs to the ADP-ribosyltransferase family and is a GPI-anchored protein with a molecular mass of about 30 kDa while DOK1 is an adapter protein with a molecular mass around 50 kDa. ART4 is expressed on erythrocytes and some lymphocyte subpopulations and DOK1 is expressed in various tissues most notably in hematopoietic cells.

Biological function summary

The two proteins engage in distinct functions within cellular mechanisms. ART4 participates in cell communication and receptor signaling on the cell surface. DOK1 acts as a modulator of signal transduction being part of signalosome complexes. Their interaction facilitates proper signaling which influences cell growth and immune responses.

Pathways

Proteins like ART4 and DOK1 play relevant roles in regulating immune cell function and hematopoiesis. ART4 is involved in the complement pathway while DOK1 connects to the Ras-MAPK signaling pathway. These proteins position themselves alongside major signaling molecules like SHC and GRB2 which participate in signal transduction cascades.

ART4 and DOK1 have implications in autoimmune diseases and leukemia. In autoimmune disorders abnormal ART4 expression alters immune responses. In leukemia DOK1's regulation of cell proliferation links it to leukemia progression correlating with proteins such as ABL1 in signaling abnormalities.

style

left-column

製品の性状

製品の状態

Liquid

補足情報

Affinity purified

style

left-column

一般的な情報

配列の類似性

Belongs to the Arg-specific ADP-ribosyltransferase family.

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

See full target information ART4

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant Human ART4/DOK1 protein (His tag C-Terminus)