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AB171472

Recombinant Human APOBEC4 protein (denatured) (His tag N-Terminus)

Recombinant Human APOBEC4 protein (denatured) (His tag N-Terminus)

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Recombinant Human APOBEC4 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

C1orf169, APOBEC4, Putative C->U-editing enzyme APOBEC-4, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4

1 Images
SDS-PAGE - Recombinant Human APOBEC4 protein (denatured) (His tag N-Terminus) (AB171472)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human APOBEC4 protein (denatured) (His tag N-Terminus) (AB171472)

15% SDS-PAGE analysis of 3µg ab171472.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q8WW27

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEKKKKKGKK","proteinLength":"Full Length","predictedMolecularWeight":"44 kDa","actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WW27","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

APOBEC4 is a member of the APOBEC family of proteins which are cytidine deaminases known for their role in editing RNA and DNA sequences. This protein with a mass of approximately 43 kDa shows expression in various human tissues but is particularly noted in testis. It operates by converting cytidine to uridine in single-stranded DNA which suggests it might participate in genetic regulation processes along with other APOBEC proteins.
Biological function summary

APOBEC4 participates in mutational processes that potentially contribute to genomic diversity. Although detailed functions remain less understood compared to its family members there is evidence to suggest its involvement in germ cell mutation processes. It doesn't expressly form any identified complex like other well-characterized APOBEC members but its potential role might involve interactions that influence genetic sequence variation.

Pathways

APOBEC4's actions can imply a role in pathways involving nucleic acid metabolism. It aligns with pathways linked to RNA modification and potentially impacts the integrity of genetic information during transcription. Other proteins like APOBEC3A and APOBEC3B also participate in similar mutational and editing processes reflecting a possible overlap in pathway involvement that suggests a regulatory network maintaining genetic fidelity.

APOBEC4 remains not fully implicated yet its family members have known roles in cancer pointing to a potential link. Its functions tie to disorders associated with genomic instability possibly connecting with mutagenic activities leading to oncogenesis. Examination of APOBEC4 within cancer pathways involves looking at how APOBEC3 proteins also contribute to tumorigenesis hinting at a shared mechanistic influence across this protein family.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Putative C to U editing enzyme whose physiological substrate is not yet known.

配列の類似性

Belongs to the cytidine and deoxycytidylate deaminase family.

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製品プロトコール

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ターゲットの情報

Putative C to U editing enzyme whose physiological substrate is not yet known.
See full target information APOBEC4
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