AB109158

Recombinant human ANGPTL7 protein

Bioactive
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Recombinant human ANGPTL7 protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in HEK 293 cells, with >90%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein

Key facts

精製度

>90% SDS-PAGE

エンドトキシンレベル

< 0.1 EU/µg

発現系

HEK 293 cells

アプリケーション

SDS-PAGE

applications

生物活性

Yes

生物学的活性

Activates ERK phosphorylation in THP1 cells.

アクセッション番号

O43827

アニマルフリー

キャリアフリー

Yes

種

Human

バッファー組成

Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"45 kDa","actualMolecularWeight":null,"aminoAcidEnd":346,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"O43827","tags":[{"tag":"DDDDK","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

True

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The ANGPTL7 protein also known as Angiopoietin-like 7 plays a role in mechanistic processes. It has a molecular mass of about 45 kDa. ANGPTL7 is expressed primarily in the cornea and trabecular meshwork of the eye but it is also found in other tissues like the liver and heart. This protein is part of the larger angiopoietin-like protein family which is involved in numerous functions related to angiogenesis and metabolism.

Biological function summary

ANGPTL7 participates in the regulation of extracellular matrix composition and collagen deposition affecting tissue remodeling. It does not form a known complex with other molecules but influences the structural integrity of tissues through its regulatory actions. ANGPTL7 potentially interacts with cellular receptors to mediate these effects contributing to maintenance and repair of tissue structures.

Pathways

ANGPTL7 interacts within the framework of the TGF-beta signaling pathway influencing cellular growth and differentiation. Another important pathway involving ANGPTL7 is the Wnt signaling cascade which is important for various developmental processes. In these pathways ANGPTL7 has functional interactions with proteins such as TGF-beta and beta-catenin modulating their activity and impact on cellular functions.

ANGPTL7 has connections to ocular diseases like glaucoma where its expression levels alter the outflow facility of aqueous humor. It also relates to fibrosis since the regulation of collagen deposition is an important factor. The involvement of ANGPTL7 in these conditions links it with proteins such as myocilin in glaucoma and TIMP-1 in fibrosis highlighting its role in pathological tissue remodeling.

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製品の性状

製品の状態

Liquid

補足情報

ab109158 is an 0.2 µm filtered solution.

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一般的な情報

機能

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed : 21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed : 25622036).

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information ANGPTL7

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Recombinant human ANGPTL7 protein