Recombinant Human Alpha B Crystallin protein (ab48779)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: Functional Studies, SDS-PAGE, WB
製品の詳細
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製品名
Recombinant Human Alpha B Crystallin protein
Alpha B Crystallin タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK -
予測される分子量
20 kDa -
領域
1 to 175
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab48779 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
SDS-PAGE
Western blot
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.316% Tris HCl, 0.0292% EDTA, 0.29% Sodium chloride
関連情報
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別名
- AACRYA
- Alpha B crystallin
- Alpha crystallin B chain
see all -
機能
May contribute to the transparency and refractive index of the lens. -
組織特異性
Lens as well as other tissues. -
関連疾患
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
配列類似性
Belongs to the small heat shock protein (HSP20) family. -
細胞内局在
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human Alpha B Crystallin protein (ab48779)14% SDS-PAGE gel loaded with ab48779,
recombinant Human alpha B Crystallin,
predicted molecular weight 20.1 kDa -
Western blot - Recombinant Human Alpha B Crystallin protein (ab48779)
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab48779 は 4 報の論文で使用されています。
- Eschbach J et al. Drug upgrade: A complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique. Drug Dev Res 85:e22151 (2024). PubMed: 38349254
- Waddingham MT et al. Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome. Physiol Rep 11:e15788 (2023). PubMed: 37985159
- Kötter S et al. Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins. J Cell Biol 204:187-202 (2014). PubMed: 24421331
- Rao NA et al. Small Heat Shock Protein aA-Crystallin Prevents Photoreceptor Degeneration in Experimental Autoimmune Uveitis. PLoS One 7:e33582 (2012). PubMed: 22479415