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AB153160

Recombinant Human ADAMTS7 protein (GST tag N-Terminus)

Recombinant Human ADAMTS7 protein (GST tag N-Terminus)

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Recombinant Human ADAMTS7 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1589 to 1686 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, ADAMTS7

1 Images
SDS-PAGE - Recombinant Human ADAMTS7 protein (GST tag N-Terminus) (AB153160)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ADAMTS7 protein (GST tag N-Terminus) (AB153160)

ab153160 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB

applications

生物活性

No

アクセッション番号

Q9UKP4

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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組合せ製品

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Proteins & Peptides

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"VQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSRGHQRVARR","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":1686,"aminoAcidStart":1589,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UKP4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS7 also known as ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 is an enzyme with a molecular mass of approximately 180 kDa. This protein is part of the ADAMTS family characterized by a disintegrin and metalloproteinase with thrombospondin motifs. ADAMTS7 is expressed mainly in the human kidney liver and skeletal muscle tissues. This protein plays a significant role in the degradation and remodeling of the extracellular matrix mediating processes such as protein processing and extracellular matrix assembly.
Biological function summary

ADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.

Pathways

ADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.

ADAMTS7 has a connection to atherosclerosis and osteoarthritis. In atherosclerosis ADAMTS7 influences the remodeling of vascular tissues with effects on arterial stiffness and plaque stability. It interacts with proteins like low-density lipoprotein receptor-related protein 1 (LRP1) affecting lipid accumulation and inflammatory responses. In osteoarthritis ADAMTS7 contributes to cartilage degradation linking with other matrix-degrading enzymes to influence the progression of joint degeneration and inflammation.
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一般的な情報

機能

Metalloprotease (PubMed : 16585064, PubMed : 39672391). Was previously shown to degrade COMP (PubMed : 16585064). However, a later study found no activity against COMP (PubMed : 39672391).

翻訳後修飾

N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion.. O-glycosylated proteoglycan; contains chondroitin sulfate.. May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed (PubMed:15192113).

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製品プロトコール

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ターゲットの情報

Metalloprotease (PubMed : 16585064, PubMed : 39672391). Was previously shown to degrade COMP (PubMed : 16585064). However, a later study found no activity against COMP (PubMed : 39672391).
See full target information A disintegrin and metalloproteinase with thrombospondin motifs 7
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