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AB153343

Recombinant Human 24p3R protein (GST tag N-Terminus)

Recombinant Human 24p3R protein (GST tag N-Terminus)

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Recombinant Human 24p3R protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 538 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

BOCT, BOIT, SLC22A17, Solute carrier family 22 member 17, 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, 24p3R, NgalR

1 Images
SDS-PAGE - Recombinant Human 24p3R protein (GST tag N-Terminus) (AB153343)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human 24p3R protein (GST tag N-Terminus) (AB153343)

ab153343 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB

applications

生物活性

No

アクセッション番号

Q8WUG5

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":538,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WUG5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The 24p3R also known as SLC22A17 or neutrophil gelatinase-associated lipocalin receptor is a receptor protein that facilitates cellular uptake of its ligand the neutrophil gelatinase-associated lipocalin (NGAL) known scientifically as lipocalin-2. This receptor with a molecular mass of approximately 55 kDa participates in iron regulation by binding and internalizing iron-laden NGAL. Expression of 24p3R occurs across various tissues with significant presence in kidney liver and spleen reflecting its systemic role in iron homeostasis.
Biological function summary

The NGAL and 24p3R interaction plays a critical role in iron metabolism and immune response. The receptor delivers NGAL-bound iron to cells impacting the cell's iron availability an essential process for many cellular functions and maintaining systemic iron balance. This interaction does not occur in isolation; 24p3R operates within a larger complex network involving other iron-regulating proteins like transferrin which collectively orchestrate iron absorption distribution and storage in the body.

Pathways

24p3R functions within the iron metabolism pathway essential for iron uptake and regulation. Its interaction with NGAL is related to the transferrin receptor pathway which regulates iron uptake through transferrin-bound iron. These interactions highlight the role of 24p3R beyond the basic cellular uptake of NGAL influencing systemic iron distribution and maintaining cellular iron homeostasis. Proteins like transferrin family members modulate this pathway and are integral to the function of 24p3R in cellular iron control.

24p3R involvement is directly linked to conditions characterized by iron imbalance such as iron deficiency anemia and chronic kidney disease. Aberrant expression or function of 24p3R can contribute to these diseases through disturbed iron metabolism. In these contexts NGAL levels often elevated act as markers of disrupted iron homeostasis and inflammation further associating 24p3R with the pathological processes. By connecting with NGAL 24p3R plays a role in these diseases highlighting its importance in maintaining iron equilibrium in health and disease.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

配列の類似性

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

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製品プロトコール

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ターゲットの情報

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
See full target information SLC22A17
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組合せ製品

Reagents, Controls & Accessories

AB116027

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB116027)

  • 5
  • 2
Primary Antibodies

AB237539

Anti-24p3R antibody

Immunocytochemistry/ Immunofluorescence - Anti-24p3R antibody (AB237539)

  • 0
  • 0
Proteins & Peptides

AB187960

Lipocalin-2 / NGAL peptide

  • 0
  • 0
Primary Antibodies

AB125075

Anti-Lipocalin-2 / NGAL antibody [EPR5084]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lipocalin-2 / NGAL antibody [EPR5084] (AB125075)

  • 5
  • 1
Assay Kits

AB199083

Mouse Lipocalin-2 ELISA Kit (NGAL)

Recombinant|SimpleStep

ELISA - Mouse Lipocalin-2 ELISA Kit (NGAL) (AB199083)

  • 5
  • 2

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