Recombinant Hepatitis B Virus Core Antigen protein (ab49014)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: WB, ELISA
製品の詳細
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製品名
Recombinant Hepatitis B Virus Core Antigen protein
Hepatitis B Virus Core Antigen タンパク質・ペプチド 製品一覧 -
生理活性
Reacts strongly with human HBV positive serum. -
精製度
> 95 % SDS-PAGE. -
発現系
Escherichia coli -
タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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領域
1 to 144 -
配列の追加情報
Deleted DNA binding domain. Fully competent for self-assembly.
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特性
Our Abpromise guarantee covers the use of ab49014 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Western blot
ELISA
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製品の状態
Liquid -
備考
During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,
Reacts strongly with human HBV positive serum. -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.20
Constituents: 0.02% PBS, 50% Glycerol (glycerin, glycerine), 0.435% Sodium chloride
関連情報
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別名
- C
- Capsid protein
- core
see all -
関連性
Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection. -
細胞内局在
Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab49014 は 2 報の論文で使用されています。
- Colant N et al. Escherichia Coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles. Vaccines (Basel) 9:N/A (2021). PubMed: 33669126
- Granovski V et al. Humoral Immune Response in Mice Elicited by Combined Yeast-Derived Hepatitis B Virus Core, Surface, and Mosaic Surface Antigens. Intervirology 60:90-101 (2017). PubMed: 28957812