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AB43040

Recombinant Cytomegalovirus Glycoprotein B

Recombinant Cytomegalovirus Glycoprotein B

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(6 Publications)

Recombinant Cytomegalovirus Glycoprotein B is a Human herpesvirus 5 strain AD169 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

別名を表示する

UL55, gB, Envelope glycoprotein B

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

タグ

Tag free

アプリケーション

WB, ELISA

applications

生物活性

No

アクセッション番号

P06473

アニマルフリー

No

キャリアフリー

No

種

Human herpesvirus 5 strain AD169

バッファー組成

pH: 7.2 Constituents: 50% Glycerol (glycerin, glycerine), 0.395% Tris HCl, 0.0292% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P06473","tags":[]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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製品の性状

製品の状態

Liquid

補足情報

Sepharose derived purification.

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一般的な情報

機能

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Participates also in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

配列の類似性

Belongs to the herpesviridae glycoprotein B family.

翻訳後修飾

A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.

細胞内局在性

Host endosome membrane

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製品プロトコール

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ターゲットの情報

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Participates also in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
See full target information gB
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Cell 186:1417-1431.e20 PubMed37001502

2023

Cytotoxic CD4 T cells eliminate senescent cells by targeting cytomegalovirus antigen.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuya Hasegawa,Tomonori Oka,Heehwa G Son,Valeria S Oliver-García,Marjan Azin,Thomas M Eisenhaure,David J Lieb,Nir Hacohen,Shadmehr Demehri

Nature communications 14:1041 PubMed36823200

2023

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Applications

Unspecified application

Species

Unspecified reactive species

A C Gomes,I A Baraniak,A Lankina,Z Moulder,P Holenya,C Atkinson,G Tang,T Mahungu,F Kern,P D Griffiths,M B Reeves

Frontiers in immunology 13:1083230 PubMed36591233

2022

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.

Applications

Unspecified application

Species

Unspecified reactive species

Emma L Davies,Mahlaqua Noor,Eleanor Y Lim,Charlotte J Houldcroft,Georgina Okecha,Claire Atkinson,Matthew B Reeves,Sarah E Jackson,Mark R Wills

PLoS pathogens 15:e1008064 PubMed31841557

2019

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Simone I Richardson,Bronwen E Lambson,Andrew R Crowley,Arman Bashirova,Cathrine Scheepers,Nigel Garrett,Salim Abdool Karim,Nonhlanhla N Mkhize,Mary Carrington,Margaret E Ackerman,Penny L Moore,Lynn Morris

Journal of pharmaceutical and biomedical analysis 156:372-378 PubMed29758495

2018

A rapid magnetic particle-based enzyme immunoassay for human cytomegalovirus glycoprotein B quantification.

Applications

Unspecified application

Species

Unspecified reactive species

F Pires,M Julia Arcos-Martinez,A Cristina Dias-Cabral,Juan C Vidal,Juan R Castillo

Scientific reports 7:937 PubMed28428537

2017

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice.

Applications

ELISA

Species

Unspecified reactive species

Lindsey B Crawford,Rebecca Tempel,Daniel N Streblow,Craig Kreklywich,Patricia Smith,Louis J Picker,Jay A Nelson,Patrizia Caposio
View all publications
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Primary Antibodies

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Secondary Antibodies

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