Recombinant cynomolgus monkey ACE2 protein (ab289785)
Key features and details
- Expression system: Mammalian
- Purity: >= 93% SDS-PAGE
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant cynomolgus monkey ACE2 protein
ACE2 タンパク質・ペプチド 製品一覧 -
生理活性
Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 5 μg/ml can bind ab289785, the EC50 is 5.638-9.496 ng/ml.
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精製度
>= 93 % SDS-PAGE. -
発現系
Mammalian -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
Yes -
由来
Recombinant -
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生物種
Cynomolgus monkey -
配列
QSTIEEQAKT FLDKFNHEAE DLFYQSSLAS WNYNTNITEE NVQNMNNAGE KWSAFLKEQS TLAQMYPLQE IQNLTVKLQL QALQQNGSSV LSEDKSKRLN TILNTMSTIY STGKVCNPNN PQECLLLDPG LNEIMEKSLD YNERLWAWEG WRSEVGKQLR PLYEEYVVLK NEMARANHYK DYGDYWRGNY EVNGVDGYDY NRDQLIEDVE RTFEEIKPLY EHLHAYVRAK LMNAYPSYIS PTGCLPAHLL GDMWGRFWTN LYSLTVPFGQ KPNIDVTDAM VNQAWNAQRI FKEAEKFFVS VGLPNMTQGF WENSMLTDPG NVQKVVCHPT AWDLGKGDFR IIMCTKVTMD DFLTAHHEMG HIQYDMAYAA QPFLLRNGAN EGFHEAVGEI MSLSAATPKH LKSIGLLSPD FQEDNETEIN FLLKQALTIV GTLPFTYMLE KWRWMVFKGE IPKDQWMKKW WEMKREIVGV VEPVPHDETY CDPASLFHVS NDYSFIRYYT RTLYQFQFQE ALCQAAKHEG PLHKCDISNS TEAGQKLLNM LKLGKSEPWT LALENVVGAK NMNVRPLLNY FEPLFTWLKD QNKNSFVGWS TDWSPYADQS IKVRISLKSA LGDKAYEWND NEMYLFRSSV AYAMRTYFLE IKHQTILFGE EDVRVADLKP RISFNFYVTA PKNVSDIIPR TEVEEAIRIS RSRINDAFRL NDNSLEFLGI QTTLAPPYQS PVTT -
予測される分子量
113 kDa including tags -
領域
18 to 741 -
タグ
Fc tag C-Terminus -
配列の追加情報
Human Fc tag
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特性
Our Abpromise guarantee covers the use of ab289785 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituents: 0.79% Sodium chloride, 0.02% Potassium chloride, 0.14% Dibasic monohydrogen sodium phosphate, 0.024% Monobasic dihydrogen potassium phosphate, 6% TrehaloseThis product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- ACE 2
- ACE related carboxypeptidase
- ACE-related carboxypeptidase
see all -
機能
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. -
組織特異性
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. -
配列類似性
Belongs to the peptidase M2 family. -
翻訳後修飾
N-glycosylation on Asn-90 may limit SARS infectivity. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
画像
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SDS-PAGE - Recombinant cynomolgus monkey ACE2 protein (ab289785)SDS-PAGE analysis of ab289785
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab289785 は論文での使用が確認できていません。
