Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online

Native Human Human IgG3 protein (ab184884)

Submit a review Submit a question
SDS-PAGE - Native Human IgG3 protein (ab184884)

    Key features and details

    • Expression system: Native
    • Purity: > 95% SDS-PAGE
    • Suitable for: SDS-PAGE

    製品の詳細

    • 製品名

      Native Human Human IgG3 protein

    • 精製度

      > 95 % SDS-PAGE.

    • 発現系

      Native

    • アクセッション番号

      P01860

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Native

      • 生物種

        Human

      • 配列

        ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVEL KTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSC DTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYK CKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVK GFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQG NIFSCSVMHEALHNRFTQKSLSLSPGK

      • 予測される分子量

        170 kDa

      • 領域

        1 to 377

      • 配列の追加情報

        Prepared from Human plasma

    特性

    Our Abpromise guarantee covers the use of ab184884 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      SDS-PAGE

    • 製品の状態

      Liquid

    • 備考

      Like IgG1, IgG3 activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection.

      ab184884 is non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on Dry Ice. Store at -80°C.

      pH: 7.40
      Preservative: 0.05% Sodium azide
      Constituents: 0.28% Sodium phosphate, 0.88% Sodium chloride

    関連情報

    • 別名

      • DKFZp686H11213
      • FLJ39988
      • FLJ40036
      • FLJ40253
      • FLJ40587
      • FLJ40789
      • FLJ40834
      • G3m marker
      • HDC
      • Heavy chain disease protein
      • Ig gamma 3 chain C region
      • IgG3
      • IGHG 3
      • IGHG3
      • IGHG3 protein
      • Immunoglobulin gamma 3
      • Immunoglobulin gamma 3 (Gm marker)
      • Immunoglobulin heavy constant gamma 3
      • Immunoglobulin heavy constant gamma 3 (G3m marker)
      • MGC45809
      see all

    • 関連性

      IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).

    • 細胞内局在

      Secreted

    画像

    • SDS-PAGE - Native Human IgG3 protein (ab184884)
      SDS-PAGE - Native Human IgG3 protein (ab184884)

      Lane 1: Human IgG3 (20µl) Non reducing

      Lane 2: Human IgG3 (10µl) Non reducing

      Lane 3: Human IgG3 (5µl) Non reducing

      Lane 4: Human IgG3 (20µl) Reducing

      Lane 5: Human IgG3 (10µl) Reducing

      Lane 6: Human IgG3 (5µl) Reducing

      Lane 7: Molecular weigth marker

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab184884 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab184884 は論文での使用が確認できていません。

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    There are currently no Customer reviews or Questions for ab184884.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com