AB7528

Native Cow Collagen III protein

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(1 Publication)

Native Cow Collagen III protein is a Cow Full Length protein, expressed in Native, suitable for ELISA, IP, WB, SDS-PAGE.

別名を表示する

Collagen alpha-1(III) chain, COL3A1

Key facts

発現系

Native

アプリケーション

SDS-PAGE, ELISA, WB, IP

applications

生物活性

アクセッション番号

P04258

アニマルフリー

キャリアフリー

種

Cow

バッファー組成

Constituents: 3% Acetic acid

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/10000", "notes":"" }, "IP": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000", "notes":"Not recommended for use under denaturing conditions in WB, IP, and ELISA. We would suggest testing it under native conditions." }, "SDS-PAGE": { "reactivity":"NO_EXPERIMENTAL_DATA_EXPECTED_TO_REACT", "dilution-info":"", "notes":"" } } }

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製品の詳細

The product has been prepared from bovine placenta and is chromatographically and immunologically pure.

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配列情報

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Native","expressionSystem":null,"accessionNumber":"P04258","tags":[]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Collagen type III also known as COL3 and collagen III is a fibrillar protein with an approximate molecular mass of 138 kDa. This protein is a significant component of the extracellular matrix and is mainly expressed in connective tissues like skin lungs and vascular walls. You can also find it in developing tissues and fibrotic tissues reflecting its role during tissue growth and repair processes.

Biological function summary

Collagen type III contributes to maintaining the structural integrity of tissues. It forms a complex with collagen type I providing a scaffold that ensures mechanical strength and stability to tissues. This structural pairing of collagen type I and III highlights their cooperative function in supporting the extracellular matrix and regulating cell behavior in tissue repair and wound healing processes.

Pathways

Collagen type III is integral to the processes of tissue repair and fibrosis pathways. It interacts closely with proteins such as fibronectin and integrins contributing to the cellular adhesion and signaling pathways important for fibroblast function and migration. These interactions reflect its essential role in matrix assembly and stability influencing how cells respond to injury and repair damaged tissues.

Collagen type III mutations or dysregulation associate with vascular Ehlers-Danlos syndrome and keloids. In vascular Ehlers-Danlos syndrome defective collagen III compromises vessel wall integrity resulting in vascular fragility and rupture. In the context of keloids excessive collagen III accumulation in the skin illustrates its role in pathological fibrosis. Collagen type I is another protein that plays an important role in these conditions contributing along with collagen type III to the altered structural and functional properties observed in these disorders.

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製品の性状

製品の状態

Liquid

補足情報

Bovine Collagen Type III has been prepared from bovine placenta and is chromatographically and immunologically pure. Bovine Collagen Type III is free from other collagens, serum proteins and non-collagen extracellular matrix proteins.

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一般的な情報

機能

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).

配列の類似性

Belongs to the fibrillar collagen family.

翻訳後修飾

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information COL3A1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:1414 PubMed34676007

2021

Aligned nanofiber nerve conduits inhibit alpha smooth muscle actin expression and collagen proliferation by suppressing TGF-β1/SMAD signaling in traumatic neuromas.

Applications

Unspecified application

Species

Unspecified reactive species

Chenglun Yao,Xijie Zhou,Weidong Weng,Keshav Poonit,Chao Sun,Hede Yan

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Abcam product promise

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Native Cow Collagen III protein