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AB204854

Cdc25C peptide

Cdc25C peptide

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(0 Publication)

Cdc25C peptide is a Synthetic peptide. >97% and suitable for FuncS, HPLC.

別名を表示する

M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C

Key facts

精製度

>97% HPLC

タグ

Tag free

アプリケーション

HPLC, FuncS

applications

生物活性

No

アクセッション番号

P30307

アニマルフリー

No

キャリアフリー

No

種

Human

再構成

reconstitute with water at 1mg/mL

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

ab204854 (Cdc25C peptide) can be utilized as a substrate for the following active protein kinases:

ab139629 (Active human BRSK2 full length protein)
ab60762 (Active human Chk1 full length protein)
ab69918 (Active human Chk1 full length protein)
ab119135 (Active human MARK2 full length protein)
ab60012 (Active human Mark3 full length protein)
ab105211 (Active human MARK4 full length protein)
ab179497 (Active human Serine/threonine-protein kinase NIM1 full length protein)
ab125626 (Active human ARK5 full length protein)
ab105209 (Active human NUAK2 full length protein)

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配列情報

[{"sequence":"KKKVSRSGLYRSPSMPENLNRPR","proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":225,"aminoAcidStart":205,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P30307","tags":[]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
False
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製品の性状

製品の状態

Lyophilized

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一般的な情報

機能

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed : 8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed : 8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed : 8119945).

配列の類似性

Belongs to the MPI phosphatase family.

翻訳後修飾

Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed : 8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed : 8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed : 8119945).
See full target information CDC25C
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組合せ製品

Primary Antibodies

AB47322

Anti-Cdc25C (phospho S216) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cdc25C (phospho S216) antibody (AB47322)

  • 3
  • 2
Primary Antibodies

AB247671

Anti-GRK1 antibody [EPR2039(2)] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-GRK1 antibody [EPR2039(2)] - BSA and Azide free (AB247671)

  • 0
  • 0
Proteins & Peptides

AB105126

Recombinant human GRK1 protein

Functional Studies - Recombinant human GRK1 protein (AB105126)

  • 0
  • 0
Primary Antibodies

AB76076

Anti-HSF1 (phospho S326) antibody [EP1713Y]

RabMAb|Recombinant

Western blot - Anti-HSF1 (phospho S326) antibody [EP1713Y] (AB76076)

  • 4
  • 1

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