AB228946

Anti-ZNF545 抗体

Anti-ZNF545 antibody

JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal ZNF545 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZFP82.

別名を表示する

KIAA1948, ZNF545, ZFP82, Zinc finger protein 82 homolog, Zfp-82, Zinc finger protein 545

4 Images

Immunocytochemistry/ Immunofluorescence - Anti-ZNF545 antibody (AB228946)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ZNF545 antibody (AB228946)

SK-N-SH (human neuroblastoma cell line) cells stained for ZNF545 protein (green) using ab228946 at 1/500 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

Nuclear counterstain : Hoechst 33342 (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Paraffin-embedded rat hind brain tissue stained for ZNF545 using ab228946 at 1/1000 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Paraffin-embedded mouse forebrain tissue stained for ZNF545 using ab228946 at 1/1000 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Paraffin-embedded mouse colon tissue stained for ZNF545 using ab228946 at 1/1000 dilution in immunohistochemical analysis.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat, Human

アプリケーション

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ZFP82. The exact immunogen used to generate this antibody is proprietary information.

Q8N141

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ZNF545 also known as Zinc Finger Protein 545 is a transcriptional repressor that plays a role in gene expression regulation. The protein has a mass of approximately 77 kDa and contains typical C2H2 zinc finger domains that facilitate DNA binding. ZNF545 expresses mainly in the nucleus of cells within several tissues including those in the digestive and reproductive systems. It acts by binding to specific DNA sequences blocking the access of transcriptional machinery and downregulating the transcription of target genes.

Biological function summary

ZNF545 involves itself in cellular growth and proliferation processes. It functions as part of a repressive complex that influences the expression of tumor suppressor genes. The complex can modify chromatin structure by recruiting histone deacetylases which contribute to gene silencing. ZNF545's activity helps balance cell cycle progression and prevent unwanted cellular growth making it a candidate for suppressing tumorigenicity within epithelial cells.

Pathways

The protein interacts notably in pathways involved in cell cycle regulation and apoptosis. ZNF545 has a role within the p53 signaling pathway a critical pathway for maintaining cellular integrity and response to DNA damage. It potentially regulates the expression of genes within this pathway by interacting with other proteins like MDM2 which in turn modulate p53 levels and activity. This interaction ensures accurate response to cellular stress or damage preventing proliferation of damaged cells.

ZNF545 has connections to various cancers particularly gastric and nasopharyngeal carcinomas. In many cases the ZNF545 gene undergoes epigenetic silencing which leads to reduced expression and loss of its tumor-suppressing function. Methylation of its promoter region associates with the dysregulation commonly observed in these cancers. ZNF545's interaction with p53 and its impact on tumorigenic pathways highlights its importance as a therapeutic target and biomarker in oncology research.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

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Visit the Troubleshooting

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ターゲットの情報

May be involved in transcriptional regulation.

See full target information ZFP82

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastroenterology 26:3586-3602 PubMed32742128

2020

TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Feng Gu,Wei Fu,Hai-Xin Qian,Wen-Xiu Gu,Yang Zong,Qian Chen,Long Lu

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZNF545 抗体

Anti-ZNF545 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF545 antibody (AB228946)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF545 antibody (AB228946)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise