AB19165

Anti-ZMYM3 抗体

Name: Anti-ZMYM3 抗体 (ab19165) | Abcam
Brand: Abcam Limited
SKU: AB19165
Price: 75000 JPY
Availability: InStock

Anti-ZMYM3 antibody

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(2 Publications)

Rabbit Polyclonal ZMYM3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZMYM3 aa 250-300.

別名を表示する

DXS6673E, KIAA0385, ZNF261, ZMYM3, Zinc finger MYM-type protein 3, Zinc finger protein 261

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB19165)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB19165)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin basal cell carcinoma tissue labelling ZMYM3 with ab19165 at 1/5000 (0.2µg/ml). Detection : DAB.

Unknown

Western blot - Anti-ZMYM3 antibody (AB19165)

ab19165 at 0.1 ug/ml staining ZNF261 in 10 ug of Nuclear extract from HeLa cells by Western blot. Detection was by chemiluminescence with an exposure time of 15 minutes. ab19165 at 0.1 ug/ml staining ZMYM3 in 10 ug of Nuclear extract from HeLa cells by Western blot. Detection was by chemiluminescence with an exposure time of 15 minutes.

All lanes:

Western blot - Anti-ZMYM3 antibody (ab19165)

Predicted band size: 152 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human ZMYM3 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.

Q14202

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/5000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/25000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Ferret": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

This antibody was purified using an epitope specific to ZNF261 immobilized on solid support.

バッファー組成

pH: 7 - 8 Preservative: 0.1% Sodium azide Constituents: PBS, 1.764% Sodium citrate, 0.0968% Tris

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ZMYM3 also known as Zinc Finger MYM-Type Containing 3 is a protein with a molecular mass of about 155 kDa. It acts as a transcriptional regulator by binding to specific DNA sequences through its zinc-finger domains. ZMYM3 is mainly expressed in the brain and testes suggesting its role in neural and reproductive functions. The protein localizes primarily in the nucleus where it interacts with chromatin to modulate the expression of target genes.

Biological function summary

There are multiple roles of ZMYM3 in cellular processes. It is part of the CoREST complex a multiprotein scaffold involved in transcriptional repression. Through its participation in this complex ZMYM3 contributes to chromatin remodeling and epigenetic silencing of genes playing a role in maintaining the balance of gene expression necessary for normal cellular operations and development.

Pathways

There are several ways ZMYM3 impacts cellular communication and regulation. The protein is involved in the Notch signaling pathway which is important for cell differentiation proliferation and apoptotic processes. ZMYM3 influences this pathway alongside related proteins such as CoREST and LSD1. Additionally it interacts within the androgen receptor signaling pathway potentially impacting gene transcription relevant to sexual development and hormone response.

There is significant interest in the connection between ZMYM3 and cognitive impairments including X-linked intellectual disability. Mutations or dysregulation in ZMYM3 can lead to disrupted transcriptional control linking the protein to neurological disorders. Another medical condition linked to ZMYM3 is prostate cancer where it may affect androgen receptor pathways thereby implicating interactions with proteins like LSD1 and the androgen receptor itself in the disease's progression.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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ターゲットの情報

Plays a role in the regulation of cell morphology and cytoskeletal organization.

See full target information ZMYM3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature 582:426-431 PubMed32461690

2020

Ensuring meiotic DNA break formation in the mouse pseudoautosomal region.

Applications

Unspecified application

Species

Unspecified reactive species

Laurent Acquaviva,Michiel Boekhout,Mehmet E Karasu,Kevin Brick,Florencia Pratto,Tao Li,Megan van Overbeek,Liisa Kauppi,R Daniel Camerini-Otero,Maria Jasin,Scott Keeney

Development (Cambridge, England) 145: PubMed30126904

2018

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance.

Applications

Unspecified application

Species

Unspecified reactive species

Hue M La,Ai-Leen Chan,Julien M D Legrand,Fernando J Rossello,Christina G Gangemi,Antonella Papa,Qiang Cheng,Eric F Morand,Robin M Hobbs

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-ZMYM3 抗体

Anti-ZMYM3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB19165)

Western blot - Anti-ZMYM3 antibody (AB19165)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise