Anti-ZIP Kinase 抗体 - C-terminal (ab186066)
Key features and details
- Rabbit polyclonal to ZIP Kinase - C-terminal
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ZIP Kinase antibody - C-terminal
ZIP Kinase 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ZIP Kinase - C-terminal -
由来種
Rabbit -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Human
交差が予測される動物種: Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
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免疫原
Recombinant fragment within Human ZIP Kinase aa 400 to the C-terminus (C terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: O43293 -
ポジティブ･コントロール
- HeLa whole cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab186066の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP |
Use at 2-10 µg/mg of lysate.
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| 特記事項 |
|---|
|
IP
Use at 2-10 µg/mg of lysate. |
ターゲット情報
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機能
Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. -
配列類似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 1 protein kinase domain. -
翻訳後修飾
Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus.
Autophosphorylated. Phosphorylated by ROCK1. -
細胞内局在
Nucleus. Cytoplasm. Nucleus > PML body. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase. - Information by UniProt
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参照データベース
- Entrez Gene: 455594 Chimpanzee
- Entrez Gene: 476745 Dog
- Entrez Gene: 1613 Human
- Entrez Gene: 714221 Rhesus monkey
- Omim: 603289 Human
- SwissProt: O43293 Human
- Unigene: 631844 Human
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別名
- DAP kinase 3 antibody
- DAP like kinase antibody
- DAP-like kinase antibody
see all
画像
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Immunoprecipitation - Anti-ZIP Kinase antibody - C-terminal (ab186066)
Immunoprecipitation of 20μg HeLa lysate labelling ZIP Kinase with ab186066 at 6 μg/mg lysate. Secondary antibody used at 1μg/ml dilution.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab186066 は論文での使用が確認できていません。