AB47116

Anti-Zinc Alpha 2 Glycoprotein 抗体

Name: Anti-Zinc Alpha 2 Glycoprotein 抗体 (ab47116) | Abcam
Brand: Abcam Limited
SKU: AB47116
Price: 69000 JPY
Availability: InStock

Anti-Zinc Alpha 2 Glycoprotein antibody

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(2 Publications)

Rabbit Polyclonal Zinc Alpha 2 Glycoprotein antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AZGP1 aa 1 to C-terminus.

別名を表示する

ZAG, ZNGP1, AZGP1, Zinc-alpha-2-glycoprotein, Zn-alpha-2-GP, Zn-alpha-2-glycoprotein

2 Images

Unknown

Western blot - Anti-Zinc Alpha 2 Glycoprotein antibody (AB47116)

All lanes:

Western blot - Anti-Zinc Alpha 2 Glycoprotein antibody (ab47116) at 1 µg/mL

Lane 1:

Human Plasma Total Protein Lysate at 10 µg

Lane 2:

Human liver tissue lysate - total protein (ab29889) at 10 µg

Lane 3:

Human testis tissue lysate - total protein (ab30257) at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 34 kDa

Observed band size: 43 kDa,55 kDa

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Exposure time: 30s

CiteAb

Western blot - Anti-Zinc Alpha 2 Glycoprotein antibody (AB47116)

Zinc Alpha 2 Glycoprotein western blot using anti-Zinc Alpha 2 Glycoprotein antibody ab47116. Publication image and figure legend from Shetty, V., Hafner, J., et al., 2012, Clin Proteomics, PubMed 22856521.

ab47116 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab47116 please see the product overview.

Western blot analysis : a) Validation of differentially sialylated glycoproteins b) Investigation of O-sialylated glycoprotein contribution c) Pooling vs individual patient sample analysis.

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Recombinant Fragment Protein within Human AZGP1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P25311

特異性

This antibody is specific for Zinc Alpha 2 Glycoprotein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

Immunoaffinity chromatography on a column with immobilized recombinant human Zinc Alpha 2 Glycoprotein.

バッファー組成

Constituents: PBS, 0.58% Sodium chloride

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Zinc Alpha 2 Glycoprotein (ZAG) also called ZAG or AZGP1 is a soluble protein with a molecular mass of approximately 41 kDa. It functions as an adipokine and is mostly found in the liver breast and prostate tissues as well as in bodily fluids like plasma and saliva. ZAG belongs to the major histocompatibility complex class I family and it shares structural similarities with antigen-presenting proteins.

Biological function summary

Zinc Alpha 2 Glycoprotein assists in lipid metabolism. It promotes the breakdown of triglycerides in adipose tissue by stimulating the beta-adrenergic pathway. ZAG functions independently and does not typically form complexes with other proteins during this process. Its presence in adipose tissue suggests a role in energy homeostasis and body weight regulation.

Pathways

Zinc Alpha 2 Glycoprotein participates in the metabolic pathway for lipid degradation. The protein interacts with beta-3 adrenergic receptors to trigger lipolysis which involves breaking down fat cells into free fatty acids and glycerol. Its action in this pathway links ZAG with other proteins such as perilipin which protects lipid droplets from breakdown.

Zinc Alpha 2 Glycoprotein has connections with metabolic-related conditions notably obesity and cancer cachexia. In obesity lower levels of ZAG are often observed potentially linking it to impaired fat metabolism. In cancer cachexia elevated ZAG levels are frequently detected suggesting a role in the loss of fat and muscle tissue. ZAG's interaction with certain cytokines may enhance cachexia progression by affecting protein degradation pathways.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

See full target information AZGP1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Clinical proteomics 9:10 PubMed22856521

2012

Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics.

Applications

Species

Unspecified reactive species

Vivekananda Shetty,Julie Hafner,Punit Shah,Zacharie Nickens,Ramila Philip

Journal of proteome research 9:227-36 PubMed19921957

2009

Tandem 18O stable isotope labeling for quantification of N-glycoproteome.

Applications

Species

Human

Ze Liu,Jing Cao,Yifeng He,Liang Qiao,Congjian Xu,Haojie Lu,Pengyuan Yang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Zinc Alpha 2 Glycoprotein 抗体

Anti-Zinc Alpha 2 Glycoprotein antibody

Western blot - Anti-Zinc Alpha 2 Glycoprotein antibody (AB47116)

Western blot - Anti-Zinc Alpha 2 Glycoprotein antibody (AB47116)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise