AB228834

Anti-Zhangfei 抗体

Anti-Zhangfei antibody

JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal Zhangfei antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CREBZF.

別名を表示する

ZF, CREBZF, CREB/ATF bZIP transcription factor, Host cell factor-binding transcription factor Zhangfei, HCF-binding transcription factor Zhangfei

1 Images

Supplier Data

Western blot - Anti-Zhangfei antibody (AB228834)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-Zhangfei antibody (ab228834) at 1/1000 dilution

All lanes:

Mouse brain lysate at 50 µg

Predicted band size: 37 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

applications

免疫原

Recombinant Fragment Protein within Human CREBZF. The exact immunogen used to generate this antibody is proprietary information.

Q9NS37

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Zhangfei also known as ZF or ZBTB16 acts as a transcription factor. It belongs to the BTB/POZ family and has a molecular weight of approximately 77 kDa. Researchers have found it expressed in various tissues including the central nervous system and immune cells. Zhangfei interacts mechanistically with other proteins through its BTB domain modulating transcriptional activity.

Biological function summary

This transcription factor regulates the expression of genes important for immune responses and neuronal functions. It forms part of complexes that modulate transcriptional repression often working with corepressors like N-CoR or SMRT. Zhangfei has a role in shaping developmental processes by influencing gene expression in specific lineages providing guidance during cell differentiation.

Pathways

Zhangfei influences gene regulation pathways that encompass the NF-kB and TGF-beta signaling. It interacts with proteins such as IKKs in the NF-kB pathway to modulate inflammation responses. In the TGF-beta pathway Zhangfei plays a role in cellular differentiation processes connecting with proteins like Smad3 to ensure proper signal transduction and output.

Zhangfei's dysregulation links to neurological disorders and certain cancers. It connects with proteins involved in these diseases such as p53 and c-Myc influencing cell cycle control and apoptotic pathways. Evidence suggests altered Zhangfei activity may contribute to neurodegenerative conditions and impacts tumor progression by affecting cellular growth signals.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

See full target information CREBZF

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular oncology (Dordrecht) 45:355-365 PubMed35579750

2022

Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated mA demethylation of EIF4EBP1 and MLST8 mRNA.

Applications

Unspecified application

Species

Unspecified reactive species

Le Zhang,Xiulan Su

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Zhangfei 抗体

Anti-Zhangfei antibody

Western blot - Anti-Zhangfei antibody (AB228834)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

代替製品

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise