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AB155085

Anti-ZFYVE19 抗体 [EPR9789]

Anti-ZFYVE19 antibody [EPR9789]

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(1 Publication)

Rabbit Recombinant Monoclonal ZFYVE19 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.

別名を表示する

ANCHR, MPFYVE, ZFYVE19, Abscission/NoCut checkpoint regulator, MLL partner containing FYVE domain, Zinc finger FYVE domain-containing protein 19

2 Images
Flow Cytometry (Intracellular) - Anti-ZFYVE19 antibody [EPR9789] (AB155085)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-ZFYVE19 antibody [EPR9789] (AB155085)

Intracellular flow cytometric analysis of permeabilized MCF7 cells labeling ZFYVE19 with ab155085 at 1/10 dilution (red) compared with a Rabbit IgG negative control (green).

Western blot - Anti-ZFYVE19 antibody [EPR9789] (AB155085)
  • WB

Unknown

Western blot - Anti-ZFYVE19 antibody [EPR9789] (AB155085)

All lanes:

Western blot - Anti-ZFYVE19 antibody [EPR9789] (ab155085) at 1/1000 dilution

Lane 1:

MCF7 cell lysate at 10 µg

Lane 2:

BxPC3 cell lysate at 10 µg

Lane 3:

Raji cell lysate at 10 µg

Lane 4:

Human fetal liver lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 52 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR9789

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt (Intra), WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<p><a href='/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }
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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ZFYVE19 also known as Zinc Finger FYVE-type Containing 19 or ANKFY1 is a protein characterized by the presence of an FYVE domain and ankyrin repeats. This protein has a molecular mass of approximately 104 kDa. ZFYVE19 is expressed broadly in human tissues with high expression levels in the testis brain and heart. Mechanically it plays a pivotal role in vesicular trafficking where the FYVE domain is often involved in binding phosphatidylinositol 3-phosphate on endosomal membranes assisting in the regulation of endosomal-lysosomal sorting.
Biological function summary

This protein plays a significant role in cellular processes related to membrane trafficking and endocytosis. It often participates in protein complexes related to intracellular transport ensuring proper vesicular movements within the cell. ZFYVE19 is known to associate with various molecules that facilitate communication between different cellular compartments. These interactions are essential for cellular homeostasis and affect diverse processes such as signal transduction and nutrient uptake.

Pathways

ZFYVE19 integrates itself in the endosomal-lysosomal pathway and the phosphoinositide signaling pathway. These pathways are important for maintaining cellular lipid homeostasis and endosome maturation. In its function ZFYVE19 interacts with proteins such as EEA1 a well-known early endosome antigen and RAB5A a small GTPase that regulates endocytic vesicle fusion. These interactions help orchestrate the dynamics of membrane trafficking and signal transduction.

Disruptions in ZFYVE19 function have been associated with neurodegenerative diseases and certain cancers. In the context of neurodegenerative diseases a malfunction in endosomal-lysosomal sorting can lead to the accumulation of cellular debris similar to defects observed in disorders like Alzheimer's disease. ZFYVE19's interplay with clathrin which is critical for endocytosis can influence tumorigenesis with alterations in this process contributing to oncogenic transformations in some forms of cancer. Understanding the roles played by ZFYVE19 in these diseases provides insight into potential therapeutic targets.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Key regulator of abscission step in cytokinesis : part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
See full target information ZFYVE19
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature 642:143-153 PubMed40205039

2025

Human assembloid model of the ascending neural sensory pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Il Kim,Kent Imaizumi,Ovidiu Jurjuț,Kevin W Kelley,Dong Wang,Mayuri Vijay Thete,Zuzana Hudacova,Neal D Amin,Rebecca J Levy,Grégory Scherrer,Sergiu P Pașca
View all publications
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