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AB42123

Anti-Zearalenone 抗体 [11C9]

Anti-Zearalenone antibody [11C9]

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(1 Publication)

Mouse Monoclonal Zearalenone antibody. Suitable for ELISA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Zearalenone.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

11C9

アイソタイプ

IgG1

軽鎖のタイプ

lambda

キャリアフリー

No

アプリケーション

ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/2000 - 1/10000", "ELISA-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Zearalenone also known as F-2 toxin is a non-steroidal estrogenic mycotoxin produced by Fusarium fungi. It weighs 318.4 g/mol and commonly contaminates cereal crops such as maize wheat and barley. This compound mimics estrogen by binding to estrogen receptors in various tissues affecting hormonal balance. Its expression occurs mainly in agricultural environments where Fusarium fungi thrive.
Biological function summary

Zearalenone impacts reproductive systems in animals by competing with endogenous estrogens for receptor binding leading to disruptions in reproductive cycles and development. While not part of a specific protein complex Zearalenone's interaction with estrogen receptors allows it to interfere with normal hormonal signaling pathways. This interference can affect both estrogen-dependent gene expression and cellular functions in the exposed organism.

Pathways

Zearalenone effectively alters hormonal regulation and the signaling pathways involving estrogen receptors. It can significantly influence the endocrine axis particularly affecting the hypothalamic-pituitary-gonadal (HPG) axis which controls reproductive functions. Related to the estrogen signaling pathway proteins such as estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) play key roles in mediating Zearalenone's effects.

Zearalenone's estrogenic activity contributes to reproductive disorders such as infertility and early puberty particularly in livestock. Its interference with the HPG axis and estrogen receptors including ERα and ERβ can lead to pathological changes in reproductive hormone levels. Moreover exposure to Zearalenone has associations with an increased risk of estrogen-dependent cancers like breast cancer due to its persistence in disrupted hormonal environments over time.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Zearalenone
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 17:6103-6112 PubMed40950323

2025

TRAIL-mediated armA upregulation enhances the drug resistance of by activating the PI3K/AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bu Wang,Wei Zhang,Jianhua Liu,Hongxia Zhang,Maochen Li,Xiaocui Peng,Zhihua Zhang,Ning Song
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