Anti-ZDHHC13 抗体 (ab28759)
Key features and details
- Goat polyclonal to ZDHHC13
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ZDHHC13 antibody -
製品の詳細
Goat polyclonal to ZDHHC13 -
由来種
Goat -
特異性
This antibody is expected to recognise both reported isoforms (as represented by NP_061901 and NP_001001483). -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide:
(C)FHPAREKVLRSV
, corresponding to C terminal amino acids 611-622 of Human ZDHHC13 Peptide is available as ab45682 - ZDHHC13 peptide (611-622) -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris, 0.5% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab28759の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
| 特記事項 |
|---|
This antibody gave a positive result in ELISA against the immunizing peptide.
Antibody detection limit dilution 1:32,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Palmitoyltransferase for HD and GAD2 (By similarity). Mediates Mg(2+) transport. -
配列類似性
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Contains 6 ANK repeats.
Contains 1 DHHC-type zinc finger. -
ドメイン
The DHHC domain is required for palmitoyltransferase activity. -
細胞内局在
Golgi apparatus membrane. Cytoplasmic vesicle membrane. Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. - Information by UniProt
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参照データベース
- Entrez Gene: 54503 Human
- Entrez Gene: 243983 Mouse
- Entrez Gene: 365252 Rat
- Omim: 612815 Human
- SwissProt: Q8IUH4 Human
- SwissProt: Q9CWU2 Mouse
- Unigene: 188569 Human
- Unigene: 279116 Mouse
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別名
- DHHC 13 antibody
- DHHC-13 antibody
- FLJ10852 antibody
see all
画像
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Western blot - Anti-ZDHHC13 antibody (ab28759)Anti-ZDHHC13 antibody (ab28759) at 0.1 µg/ml + Human cerebellum lysate at 35 µg
Developed using the ECL technique.Primary antibody was incubated for 1 hour.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab28759 は 3 報の論文で使用されています。
- Sun Y et al. AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis. Cancer Res 83:1062-1073 (2023). PubMed: 36701140
- Chen S et al. Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads. Nat Commun 10:877 (2019). PubMed: 30787281
- Chen S et al. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature 549:399-403 (2017). WB . PubMed: 28869973