AB117756

Anti-ZBTB2 抗体

Name: Anti-ZBTB2 抗体 (ab117756) | Abcam
Brand: Abcam Limited
SKU: AB117756
Price: 84000 JPY
Availability: InStock

Anti-ZBTB2 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZBTB2 aa 450 to C-terminus.

別名を表示する

KIAA1483, ZNF437, ZBTB2, Zinc finger and BTB domain-containing protein 2

2 Images

Unknown

Immunoprecipitation - Anti-ZBTB2 antibody (AB117756)

Detection of ZBTB2 by Western Blot of Immunprecipitate.
ab117756 at 1µg/ml staining ZBTB2 in 293T whole cell lysate immunoprecipitated using ab117756 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-ZBTB2 antibody (ab117756)

Predicted band size: 57 kDa

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Unknown

Western blot - Anti-ZBTB2 antibody (AB117756)

All lanes:

Western blot - Anti-ZBTB2 antibody (ab117756) at 0.04 µg/mL

Lane 1:

293T cell line lysate at 50 µg

Lane 2:

293T cell line lysate at 15 µg

Lane 3:

Jurkat cell line lysate at 50 µg

Lane 4:

HeLa cell line lysate at 50 µg

Lane 5:

NIH3T3 cell line lysate at 50 µg

Predicted band size: 57 kDa

true

Exposure time: 30s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

IP, WB

applications

免疫原

Synthetic Peptide within Human ZBTB2 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8N680

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Platypus": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab117756 was affinity purified using an epitope specific to ZBTB2 immobilized on solid support.

バッファー組成

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: 99% Tris buffered saline, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB2 also known as Zinc finger and BTB domain-containing protein 2 is a transcriptional regulator with a molecular mass of approximately 95 kDa. It operates by binding DNA through its zinc finger motifs and recruiting chromatin remodeling complexes via the BTB/POZ domain affecting gene expression. You can find this protein expressed in various tissues with higher presence notably in the testis brain and some tumor tissues. As a result its expression pattern suggests a significant role in cellular proliferation and differentiation.

Biological function summary

ZBTB2 influences gene transcription and modulates cell cycle progression. It does not work alone but often forms part of transcriptional complexes. Its role in repressing or activating transcription depends on its interaction partners impacting key cellular processes. The protein’s ability to regulate numerous downstream effectors underlines its importance in maintaining cellular homeostasis and normal cellular function.

Pathways

Studies show ZBTB2 involvement in the p53 signaling and Wnt pathways which are important for regulating cell cycle and apoptosis. ZBTB2 interacts with E2F1 a regulator of cell cycle progression and negatively influences p53 activity reducing its transcriptional response. This interaction links ZBTB2 to cell growth and survival pathways making it a focus for understanding complex regulatory networks within cells.

Researchers find ZBTB2 correlated with cancer and neurodevelopmental disorders. Aberrant expression of ZBTB2 has been observed in various malignancies such as colorectal and gastric cancers where it modulates oncogenic pathways. It shows interaction with the MYC proto-oncogene protein enhancing transcriptional programs associated with cell proliferation and tumor development. In neurodevelopmental contexts altered ZBTB2 function can affect neural gene expression contributing to disorders like autism spectrum disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

May be involved in transcriptional regulation.

See full target information ZBTB2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Biological trace element research : PubMed41034598

2025

Minimal Risk Doses of Cadmium Exposure Induce Histological and Functional Alterations in the Brown Adipose Tissue of Wistar Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Victor Enrique Sarmiento-Ortega,David Castillo-Pérez,Diana Moroni-González,Alfonso Diaz,Rubén Vázquez-Roque,Eduardo Brambila,Samuel Treviño

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZBTB2 抗体

Anti-ZBTB2 antibody

Immunoprecipitation - Anti-ZBTB2 antibody (AB117756)

Western blot - Anti-ZBTB2 antibody (AB117756)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise