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AB117786

Anti-ZBT10 抗体

Anti-ZBT10 antibody

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(3 Publications)

Rabbit Polyclonal ZBT10 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZBTB10 aa 50-100.

別名を表示する

RINZF, RINZFC, ZBTB10, Zinc finger and BTB domain-containing protein 10, Zinc finger protein RIN ZF

2 Images
Immunoprecipitation - Anti-ZBT10 antibody (AB117786)
  • IP

Unknown

Immunoprecipitation - Anti-ZBT10 antibody (AB117786)

Detection of ZBT10 by Western Blot of Immunprecipitate.
ab117786 at 1µg/ml staining ZBT10 in 293T whole cell lysate immunoprecipitated using ab117786 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-ZBT10 antibody (ab117786)

Predicted band size: 95 kDa

false

Western blot - Anti-ZBT10 antibody (AB117786)
  • WB

Unknown

Western blot - Anti-ZBT10 antibody (AB117786)

All lanes:

Western blot - Anti-ZBT10 antibody (ab117786) at 0.1 µg/mL

Lane 1:

293T whole cell lysates at 50 µg

Lane 2:

293T whole cell lysates at 15 µg

Lane 3:

Jurkat whole cell lysates at 50 µg

Predicted band size: 95 kDa

true

Exposure time: 30s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IP, WB

applications

免疫原

Synthetic Peptide within Human ZBTB10 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q96DT7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab117786 was affinity purified using an epitope specific to ZBT10 immobilized on solid support.
バッファー組成
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein ZBT10 also known as Zinc Finger and BTB Domain Containing 10 acts as a transcription factor. Its molecular mass is approximately 55 kDa. This protein is expressed mainly in liver cells and several immune-related tissues showing a diverse expression pattern. ZBT10 contains a BTB/POZ domain which interacts with nuclear chromatin to regulate gene transcription. This protein contains specific zinc finger motifs that play a role in binding to DNA sequences.
Biological function summary

Zinc Finger and BTB Domain Containing 10 is involved in regulating cell differentiation and proliferation. It plays a critical role in hematopoiesis processes and may take part in muscle tissue development. ZBT10 often forms a complex with other transcription factors aiding precise control of gene expression related to cell cycle progression. By modulating different transcriptional activities ZBT10 influences the expression of genes involved in developmental pathways.

Pathways

Zinc Finger and BTB Domain Containing 10 participates in the Notch signaling pathway which determines cell fate decisions. This protein interacts with CSL (CBF1/Su(H)/LAG-1) important in transducing activated Notch signals. ZBT10 indirectly affects the WNT signaling pathway by regulating transcription factors involved in cell proliferation and migration. In these pathways ZBT10 holds a position alongside key proteins like beta-catenin and jagged proteins.

Aberrations in ZBT10 expression correlate with certain cancers particularly involving the liver. Elevated or reduced levels of this protein may influence oncogenesis by altering cell proliferation rates. Additionally ZBT10 has been linked to immunological disorders by impacting immune cell differentiation; it connects with proteins such as STAT3 a critical player in immune response regulation. Understanding ZBT10's role provides insights into potential therapeutic targets for these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May be involved in transcriptional regulation.
See full target information ZBTB10
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Antioxidants (Basel, Switzerland) 12: PubMed37627542

2023

Quercetin's Dual Mode of Action to Counteract the Sp1-miR-27a Axis in Colorectal Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Emanuele Fosso,Manuela Leo,Livio Muccillo,Vittorio Maria Mandrone,Maria Chiara Di Meo,Annamaria Molinario,Ettore Varricchio,Lina Sabatino

Cell death & disease 13:252 PubMed35306527

2022

Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Ching Wen,Wei-Yu Chen,Van Thi Ngoc Tram,Hsiu-Lien Yeh,Wei-Hao Chen,Kuo-Ching Jiang,Wassim Abou-Kheir,Jiaoti Huang,Michael Hsiao,Yen-Nien Liu

Developmental cell 40:523-536.e6 PubMed28350986

2017

Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroyuki Nakajima,Kimiko Yamamoto,Sobhika Agarwala,Kenta Terai,Hajime Fukui,Shigetomo Fukuhara,Koji Ando,Takahiro Miyazaki,Yasuhiro Yokota,Etienne Schmelzer,Heinz-Georg Belting,Markus Affolter,Virginie Lecaudey,Naoki Mochizuki
View all publications
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