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AB129487

Anti-XAB2 抗体

Anti-XAB2 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal XAB2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human XAB2 aa 800 to C-terminus.

別名を表示する

HCNP, KIAA1177, SYF1, PP3898, XAB2, Pre-mRNA-splicing factor SYF1, Protein HCNP, XPA-binding protein 2

2 Images
Immunoprecipitation - Anti-XAB2 antibody (AB129487)
  • IP

Unknown

Immunoprecipitation - Anti-XAB2 antibody (AB129487)

Lane 1 : ab129487 at 0.4 µg/ml staining XAB2 in HeLa whole cell lysate immunoprecipitated using ab129487 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Lane 2 : control IgG.
Detection : Chemiluminescence
Exposure time : 3 seconds

All lanes:

Immunoprecipitation - Anti-XAB2 antibody (ab129487)

Predicted band size: 100 kDa

false

Western blot - Anti-XAB2 antibody (AB129487)
  • WB

Unknown

Western blot - Anti-XAB2 antibody (AB129487)

All lanes:

Western blot - Anti-XAB2 antibody (ab129487) at 0.04 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

293T whole cell lysate at 50 µg

Lane 4:

Jurkat whole cell lysate at 50 µg

Predicted band size: 100 kDa

true

Exposure time: 30s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IP

applications

免疫原

Synthetic Peptide within Human XAB2 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9HCS7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chinese hamster": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The XAB2 protein also known as XPA-binding protein 2 is a multi-functional protein involved in several cellular processes. It has a molecular mass of approximately 98 kDa. XAB2 locates in both the nucleus and the cytoplasm of cells indicating its involvement in processes across different cellular compartments. The expression of XAB2 is observed in various tissues suggesting its role in several biological functions.
Biological function summary

XAB2 participates in several critical processes including transcription splicing and DNA repair. It is a component of the transcription-coupled repair (TCR) machinery and plays a role in the pre-mRNA splicing process. XAB2 is part of a multiprotein complex that includes other important proteins such as the transcription factor IIH (TFIIH) and the excision repair cross-complementation group 2 (ERCC2). This complex ensures accuracy and efficiency in both gene expression and DNA repair processes.

Pathways

XAB2 plays a significant role in the nucleotide excision repair (NER) and RNA splicing pathways. It interacts with proteins like ERCC3 and ERCC2 which are also important for NER. These pathways are essential for maintaining genomic stability by repairing DNA lesions and ensuring proper mRNA processing. XAB2's involvement in these pathways highlights its importance in safeguarding genomic integrity and accurate gene expression.

Alterations in XAB2 function relate to conditions such as cancer and Cockayne syndrome. Dysfunction in NER pathways where XAB2 plays a role can lead to genomic instability contributing to the development of various cancers. In Cockayne syndrome mutations in proteins related to the NER pathway like ERCC6 highlight the connection between DNA repair deficiencies and neurodegenerative disorders. Understanding XAB2's role offers insights into these complex diseases and could help in developing therapeutic strategies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Involved in pre-mRNA splicing as component of the spliceosome (PubMed : 11991638, PubMed : 28076346, PubMed : 28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed : 10944529, PubMed : 17981804).
See full target information XAB2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastrointestinal oncology 14:2170-2182 PubMed36438699

2022

MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jing Gu,Ya-Jun Li,Fang Wang,Ting Ye

Nucleic acids research 49:9906-9925 PubMed34500463

2021

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Abhishek Bharadwaj Sharma,Hélène Erasimus,Lia Pinto,Marie-Christine Caron,Diyavarshini Gopaul,Thibaut Peterlini,Katrin Neumann,Petr V Nazarov,Sabrina Fritah,Barbara Klink,Christel C Herold-Mende,Simone P Niclou,Philippe Pasero,Patrick Calsou,Jean-Yves Masson,Sébastien Britton,Eric Van Dyck
View all publications
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