Anti-West Nile Virus preM 抗体 (ab25888)
Key features and details
- Rabbit polyclonal to West Nile Virus preM
- Suitable for: ELISA
- Reacts with: West Nile virus
- Isotype: IgG
製品の概要
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製品名
Anti-West Nile Virus preM antibody -
製品の詳細
Rabbit polyclonal to West Nile Virus preM -
由来種
Rabbit -
アプリケーション
適用あり: ELISAmore details -
種交差性
交差種: West Nile virus -
免疫原
Synthetic peptide corresponding to 15 amino acids near the middle of the West Nile Virus Matrix precursor protein.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab25888の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration. This polyclonal antibody can be used for the detection of the WNV Matrix precursor protein in ELISA. It will detect 10 ng of free peptide at 1 µg/ml.
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特記事項 |
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ELISA
Use at an assay dependent concentration. This polyclonal antibody can be used for the detection of the WNV Matrix precursor protein in ELISA. It will detect 10 ng of free peptide at 1 µg/ml. |
ターゲット情報
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関連性
West Nile Virus is part of the flavivirus family, many of which are capable of causing serious illness in humans. The ssRNA + strand virus is enveloped and spherical with a diameter of 40-50 nm, similar to all flaviviruses. The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E. Inside cells, viral particles will contain a preM particle and E in a complex that matures through proteolytic cleavage and processing in the Golgi apparatus. WNV has three different effects on humans, the first is asymptomatic infection; the second is a mild febrile syndrome termed West Nile Fever; the third is a neuroinvasive disease termed West Nile meningitis or encephalitis. In infected individuals the ratio between the three states is roughly 110:30:1. The main route of human infection is through the bite of an infected mosquito. -
参照データベース
- Entrez Gene: 912267 West Nile virus
- SwissProt: P06935 West Nile virus
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別名
- membrane glycoprotein M antibody
- membrane glycoprotein precursor prM antibody
- pre M protein antibody
- West Nile virus antibody
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab25888 は 3 報の論文で使用されています。
- Hirota J et al. Development of monoclonal antibodies to West Nile virus and their application in immunohistochemistry. Clin Vaccine Immunol : (2012). PubMed: 22993408
- Colpitts TM et al. prM-antibody renders immature West Nile virus infectious in vivo. J Gen Virol 92:2281-5 (2011). Functional Studies . PubMed: 21697345
- Schepp-Berglind J et al. Complex adenovirus-mediated expression of West Nile virus C, PreM, E, and NS1 proteins induces both humoral and cellular immune responses. Clin Vaccine Immunol 14:1117-26 (2007). ICC/IF . PubMed: 17634508