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AB169597

Anti-WDR9/BRWD1 抗体

Anti-WDR9/BRWD1 antibody

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(2 Publications)

Mouse Polyclonal WDR9/BRWD1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BRWD1.

別名を表示する

C21orf107, WDR9, BRWD1, Bromodomain and WD repeat-containing protein 1, WD repeat-containing protein 9

1 Images
Western blot - Anti-WDR9/BRWD1 antibody (AB169597)
  • WB

Unknown

Western blot - Anti-WDR9/BRWD1 antibody (AB169597)

All lanes:

Western blot - Anti-WDR9/BRWD1 antibody (ab169597) at 1 µg/mL

Lane 1:

WDR9/BRWD1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 263 kDa

true

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human BRWD1.

Q9NSI6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The WDR9/BRWD1 protein is also known by its alternate name BRWD1 and has a molecular mass of approximately 250 kDa. This protein shows expression in various tissues with higher levels observed in testis and certain brain regions. WDR9/BRWD1 is a member of the WD-repeat protein family and contains two bromodomains. Mechanically it plays a role in mediating protein-protein interactions aiding in chromatin organization and gene regulation.
Biological function summary

WDR9/BRWD1 functions in regulating transcriptional processes and is often part of nuclear chromatin complexes. It participates in gene expression important for spermatogenesis and neuronal differentiation. This protein interacts with other chromatin-modifying proteins contributing to the alteration of chromatin states and affecting cellular programs.

Pathways

Different regulatory and developmental processes involve WDR9/BRWD1. The protein plays roles within chromatin remodeling pathways. It engages with pathways such as histone modification and transcriptional regulation working alongside proteins like histones and other transcription factors which helps coordinate the accessibility of transcriptional machinery to DNA.

Abnormal WDR9/BRWD1 expression or mutations have connections to neurological and reproductive conditions. Studies link its dysregulation to intellectual disabilities and fertility issues. Its association with chromatin-modifying proteins implicates it in diseases where gene expression regulation plays a role such as certain cognitive disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
See full target information BRWD1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Human genetics 140:761-773 PubMed33389130

2021

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Guo,Chao-Feng Tu,Dan-Hui Yang,Shui-Zi Ding,Cheng Lei,Rong-Chun Wang,Lv Liu,Xi Kang,Xiao-Qing Shen,Yi-Feng Yang,Zhi-Ping Tan,Yue-Qiu Tan,Hong Luo

International journal of clinical and experimental pathology 11:2488-2496 PubMed31938361

2018

Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weichao Wang,Jie Zhang,Xiaohang Wang,Hong Wang,Qiaohua Ren,Yukun Li
View all publications
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Abcam product promise

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