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AB235046

Anti-WDR37 抗体

Anti-WDR37 antibody

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(1 Publication)

Rabbit Polyclonal WDR37 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Wdr37.

別名を表示する

Kiaa0982, Wdr37, WD repeat-containing protein 37

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)

Paraffin-embedded human colon cancer tissue stained for WDR37 using ab235046 at 1/500 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)

Paraffin-embedded human appendix tissue stained for WDR37 using ab235046 at 1/500 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Mouse Wdr37.

Q8CBE3

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組合せ製品

Primary Antibodies

AB52623

Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker (AB52623)

  • 5
  • 6
Primary Antibodies

AB245230

Anti-BRN3A antibody [EPR23257-285]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-BRN3A antibody [EPR23257-285] (AB245230)

  • 5
  • 2
Primary Antibodies

AB152101

Anti-RBPMS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBPMS antibody (AB152101)

  • 4
  • 3
Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

  • 5
  • 9
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
Purity >95%.
バッファー組成
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein WDR37 also known as WD Repeat Domain 37 functions as a scaffold protein containing several WD repeat motifs. It has a molecular weight of approximately 106 kDa. WDR37 expresses in multiple tissues including the brain heart and liver. The protein plays a role in protein-protein interactions facilitating various cellular processes by forming stable multiprotein assemblies.
Biological function summary

WDR37 participates in cell cycle regulation and signal transduction. It is a part of multiprotein complexes that influence the progression of the cell cycle and mitotic spindle formation. WDR37 aids in organizing the interactions necessary for these cellular activities which contributes to maintaining proper cellular function. It also shows involvement in neurodegenerative processes and has been implicated in the maintenance of neuronal health.

Pathways

WDR37 interacts with critical protein networks involved in the PI3K/AKT signaling pathway. This pathway is significant for cell growth survival and metabolism. WDR37's associations within this pathway influence important molecular cascades and involve interactions with proteins like AKT and PI3K helping to coordinate cellular responses. WDR37 is also involved in the Wnt signaling pathway vital for gene expression regulation and developmental processes.

WDR37-related dysfunction has been associated with intellectual disability and autism spectrum disorders. These conditions highlight the protein's importance in brain health and development. In such diseases the dysregulated interaction between WDR37 and other proteins like those involved in synaptic functions may contribute to the pathological features observed. Understanding WDR37's role further can offer insights into therapeutic options for these neurological conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations.
See full target information Wdr37
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 221: PubMed34747980

2021

Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zheng,Xi Chen,Qiang Liu,Guisheng Zhong,Min Zhuang
View all publications
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Abcam product promise

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