Anti-VPAC2 抗体 (ab28624)
Key features and details
- Rabbit polyclonal to VPAC2
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-VPAC2 antibody
VPAC2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to VPAC2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide:
LQFHRGSRAQSFLQTETSVI
conjugated to KLH, corresponding to amino acids 419-438 of Human VIP Receptor 2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab28624の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
1/500.
|
|
WB |
1/250 - 1/500. Predicted molecular weight: 49 kDa.
|
特記事項 |
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IHC-P
1/500. |
WB
1/250 - 1/500. Predicted molecular weight: 49 kDa. |
ターゲット情報
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機能
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. -
組織特異性
Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, PEER, MOLT-4, HSB, YT and Tsup-1, but not in the T-cell lines HARRIS and HUT 78. -
配列類似性
Belongs to the G-protein coupled receptor 2 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 7434 Human
- Omim: 601970 Human
- SwissProt: P41587 Human
- Unigene: 585052 Human
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別名
- Helodermin-preferring VIP receptor antibody
- PACAP type III receptor antibody
- PACAP-R-3 antibody
see all
画像
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Anti-VPAC2 antibody (ab28624) at 1/500 dilution + PC-3 cell lysate at 30 µg
Secondary
Goat anti-Rabbit IgG (H+L), HRP conjugate at 1/4000 dilution
Predicted band size: 49 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VPAC2 antibody (ab28624)
ab28624 staining Human VIP Receptor 2 in human neuroendocrine cells of the small intestine by immunohistochemistry using paraffin embedded tissue.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (11)
ab28624 は 11 報の論文で使用されています。
- Jones JR et al. Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids. Nat Commun 12:5763 (2021). PubMed: 34599158
- Shan Y et al. Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony. Neuron 108:164-179.e7 (2020). PubMed: 32768389
- Ivic I et al. VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice. PLoS One 14:e0211433 (2019). PubMed: 30682157
- Jones JR et al. SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System. J Neurosci 38:7986-7995 (2018). PubMed: 30082421
- Liu D et al. mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction. Proc Natl Acad Sci U S A 115:E3296-E3304 (2018). PubMed: 29555746