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Anti-VMAT2 抗体 (ab70808)

Reviews (1)Q&A (4)References (10)

Key features and details

  • Rabbit polyclonal to VMAT2
  • Suitable for: IHC-P, ICC/IF, WB
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-VMAT2 antibody
    VMAT2 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to VMAT2

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: IHC-P, ICC/IF, WBmore details

  • 種交差性

    交差種: Mouse, Rat, Human

  • 免疫原

    Synthetic peptide corresponding to internal residues of human, mouse and rat VMAT2.

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab70808の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
IHC-P
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration. PubMed: 26755131
WB
Use at an assay dependent concentration.
特記事項
IHC-P
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration. PubMed: 26755131
WB
Use at an assay dependent concentration.

ターゲット情報

  • 機能

    Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

  • 配列類似性

    Belongs to the major facilitator superfamily. Vesicular transporter family.

  • 細胞内局在

    Cytoplasmic vesicle membrane.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • 1110037L13Rik antibody
    • 9330105E13 antibody
    • MGC120477 antibody
    • MGC120478 antibody
    • MGC26538 antibody
    • MGC90556 antibody
    • MNAT antibody
    • Monoamine neurotransmitter transporter antibody
    • Monoamine transporter antibody
    • OTTHUMP00000020576 antibody
    • SLC18A2 antibody
    • Solute carrier family 18 (vesicular monoamine) member 2 antibody
    • Solute carrier family 18 member 2 antibody
    • SVAT antibody
    • SVMT antibody
    • Synaptic vesicle amine transporter brain antibody
    • Synaptic vesicle monoamine transporter brain antibody
    • Synaptic vesicular amine transporter antibody
    • VAT 2 antibody
    • VAT2 antibody
    • Vesicle monoamine transporter type 2 antibody
    • Vesicle monoamine/H+ antiporter antibody
    • Vesicular amine transporter 2 antibody
    • Vesicular monoamine transporter 2 antibody
    • VMAT 2 antibody
    • VMAT2 antibody
    • VMAT2_HUMAN antibody
    see all

参考文献 (10)

ab70808 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab70808 は 10 報の論文で使用されています。

  • Wang C  et al. Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson's disease rats. Ann Transl Med 10:1314 (2022). PubMed: 36660708
  • Lee HJ  et al. O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models. Antioxidants (Basel) 11:N/A (2022). PubMed: 36358479
  • Chen X  et al. Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression. Aging (Albany NY) 12:3042-3052 (2020). PubMed: 32074509
  • Huang ZH  et al. Distribution of tyrosine-hydroxylase-immunoreactive neurons in the hypothalamus of tree shrews. J Comp Neurol 528:935-952 (2020). PubMed: 31674014
  • Xu K  et al. Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice. J Neurochem 149:799-810 (2019). PubMed: 30520040
  • Zhou R  et al. Baicalin regulates the dopamine system to control the core symptoms of ADHD. Mol Brain 12:11 (2019). PubMed: 30736828
  • Iannielli A  et al. Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses. Cell Rep 29:4646-4656.e4 (2019). PubMed: 31875567
  • Jichao S  et al. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. Evid Based Complement Alternat Med 2017:2695903 (2017). WB . PubMed: 28293263
  • Zhou Q  et al. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun 7:10332 (2016). ICC/IF ; Mouse . PubMed: 26755131
  • Fossmark R  et al. ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit. APMIS 124:561-6 (2016). PubMed: 27150581

レビューと Q&A

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1-5 of 5 Abreviews or Q&A

Immunohistochemistry (Frozen sections) abreview for Anti-VMAT2 antibody

 Poor
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Pancreas)
Permeabilization
Yes - 1% triton/PBS
Specification
Pancreas
Blocking step
Blocking one(Nacalai) ) as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 20% · Temperature: 25°C
Fixative
Paraformaldehyde
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The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

投稿 Dec 27 2019

Question

Thaks for the clarification on the D2 receptor antibody. I did not catch that (goat polyclonal).Will ab97120 be a good secondary for the D2 antibody?

Thanks for the suggestions on D1 and Vmat2 antibodies. Regarding ab70808, there is a negative comment on your website when using WB on mouse tissue. Has this definitely been confirmed to work in mice (brain tissue)?

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Answer

Yes, ab97120 will pair well with ab32349.

Thank you for spotting that comment about poor mouse reactivity for ab70808, anti-Vmat2. There have not been many complaints but I did find one from a few years ago about poor staining of mouse brain. The better choice (and I should have recommended this first but I was not sure if you were willing to buy an anti-goat secondary) is ab87594 which is raised against a mouse Vmat2 peptide.

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Question

Danke schön für ihr E-Mail und die Hilfe mit den Antikörper,






Mit Freundlichen Grüßen

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Answer

DISCOUNT CODE: 100%00000

Expiration date: 09. November 2012

I am very pleased to hear you would like to accept our offer and test ab70808 in ICC/IF.

This code will give you the value of ab70808 off afuture order before the expiration date. To redeem this offer, please submit an Abreview forICC/IF and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.


Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways:
1) Call to place your order and mention the code to our customer service department;
2) Include the code in your fax order;
3) Place your order on the web and enter the promotional code.

Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.

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Question

I'm using ab70808 in WB with mouse cells and not seeing any bands.

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Answer

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with ab87594. To check the status of the order please contact our Customer Service team and reference this number.

Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.

I wish you the best of luck with your research.

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Question

Ersatzfür ab37194

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Answer

Vielen Dank für Ihren netten Anruf und für Ihr Interesse an unseren Produkten.

Wir habe drei Antikörper für die ich Ihnen eine Testing discount anbieten könnte:

ab117988
https://www.abcam.com/VMAT2-antibody-OTI10C11-ab117988.html (or use the following: https://www.abcam.com/VMAT2-antibody-OTI10C11-ab117988.html).

ab87589
https://www.abcam.com/VMAT2-antibody-C-terminal-ab87589.html (or use the following: https://www.abcam.com/VMAT2-antibody-C-terminal-ab87589.html).

ab70808
https://www.abcam.com/VMAT2-antibody-ab70808.html (or use the following: https://www.abcam.com/VMAT2-antibody-ab70808.html).

Alle drei sind getestet für IHC und werden sehr wahrscheinlich auch in ICC funktionieren.

Unserem Wissen nach wurdendiese Antikörperbisher noch nicht inICC getestet. Falls Sie dies selbst testen möchten, kann ich Ihnen zurzeit ein spezielles Angebot über einen 100%igen Abreview-Rabatt anbieten. Bei diesem Angebot bekommen Sie einen Rabatt für eine zukünftige Bestellung, wenn Sie uns ein Abreview mit dem Testresultat zusenden. Der Rabatt würde den ganzen Wert des getesteten Antikörpers abdecken, und gegen eine erneute Bestellungvon uns verrechnet werden.

Um von diesem Angebot profitieren zu können, folgen Sie bitte diesen Schritten:

1.) Bestätigen Sie mir bitte, welchen Antikörper Sie in ICC testen möchten.

2.) Bitte bestellen Sie erst nach Erhalt des Rabattcodes.

3.) Bestellen Sie den Antikörper wie üblich per Telefon, Email oder Fax

4.) Testen Sie den Antikörper in ICC .

5.) Teilen Sie uns das Ergebnis Ihres Tests durch ein Abreview mit und notieren Sie den Discount Code in dem Feld "additional notes"
Unter der folgenden URL können Sie mehr über unser Abreview System erfahren:
https://www.abcam.com/abreviews

6.) Der Rabattcode ist nach dem Abschicken des Abreviews aktiv, und Sie können ein anderes Produktzu dem gleichen Preis bei uns bestellen (halten Sie bei der Bestellung bitte den Rabattcode bereit). Bitte beachten Sie, dass der Rabattcode innerhalb von 4 Monaten nach Ausstellung eingelöst werden muss.

Der Rabattcode wird gültig unabhängig davon, ob Ihr Ergebnis positiv oder negativ ist.

Die Bedingungen zu unserem 100% Abreview Rabatt können Sie unter dem folgenden Link nachlesen:
https://www.abcam.com/collaborationdiscount

Ich hoffe, diese Informationen helfen Ihnen weiter. Falls Sie einen Rabattcode erhalten möchten oder weitere Fragen haben, zögern Sie bitte nicht, sich wieder an mich zu wenden.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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