Anti-Viperin 抗体 [MaP.VIP] (ab107359)
Key features and details
- Mouse monoclonal [MaP.VIP] to Viperin
- Suitable for: ICC/IF, IP, Flow Cyt, WB
- Reacts with: Mouse, Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-Viperin antibody [MaP.VIP]
Viperin 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MaP.VIP] to Viperin -
由来種
Mouse -
アプリケーション
適用あり: ICC/IF, IP, Flow Cyt, WBmore details
適用なし: IHC-Fr -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat
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免疫原
Recombinant fragment corresponding to amino acids 92-362 of Mouse Viperin
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
MaP.VIP -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab107359の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| Flow Cyt |
Use at an assay dependent concentration.
The typical starting working dilution is 1:50. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.
The typical starting working dilution is 1:50. |
| 特記事項 |
|---|
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ICC/IF
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. The typical starting working dilution is 1:50. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa. The typical starting working dilution is 1:50. |
ターゲット情報
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機能
Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus. -
配列類似性
Belongs to the RSAD2 family. -
細胞内局在
Endoplasmic reticulum membrane. Golgi apparatus. Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. - Information by UniProt
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参照データベース
- Entrez Gene: 91543 Human
- Entrez Gene: 58185 Mouse
- Entrez Gene: 65190 Rat
- Omim: 607810 Human
- SwissProt: Q8WXG1 Human
- SwissProt: Q8CBB9 Mouse
- SwissProt: O70600 Rat
- Unigene: 17518 Human
see all -
別名
- 2510004L01Rik antibody
- cig 33 antibody
- CIG 5 antibody
see all
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab107359 は 9 報の論文で使用されています。
- Licht-Murava A et al. Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines. Sci Adv 9:eade1282 (2023). PubMed: 37075107
- Yuan Y et al. High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction. EMBO Rep 23:e53466 (2022). PubMed: 34779558
- Tseng YY et al. Viperin has species-specific roles in response to herpes simplex virus infection. J Gen Virol 102:N/A (2021). PubMed: 34406117
- Bouvet M et al. Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus. mBio 12:N/A (2021). PubMed: 33785626
- Sarkar R et al. Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis. Viruses 13:N/A (2021). PubMed: 34372530
- Lindqvist R et al. Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. J Neuroinflammation 15:80 (2018). WB ; Mouse . PubMed: 29544502
- Upadhyay AS et al. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem 292:13879-13889 (2017). PubMed: 28615450
- Van der Hoek KH et al. Viperin is an important host restriction factor in control of Zika virus infection. Sci Rep 7:4475 (2017). PubMed: 28667332
- Tang HB et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep 6:30529 (2016). WB ; Mouse . PubMed: 27456665