AB8556

Anti-VIP 抗体

Anti-VIP antibody

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(20 Publications)

Rabbit Polyclonal VIP antibody. Suitable for ICC, IP, WB, IHC-FoFr, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 20 publications. Immunogen corresponding to Full Length Protein corresponding to Human VIP.

別名を表示する

VIP peptides, VIP

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

軽鎖のタイプ

unknown

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

IHC-P, ICC, WB, IHC-FoFr, IP

免疫原

Full Length Protein corresponding to Human VIP. The exact immunogen used to generate this antibody is proprietary information.

特異性

This antibody reacts with a 3 kD vasointestinal peptide (VIP) localized in nerve fibers in the central and peripheral nervous system. The VIP producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.

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代替製品

Primary Antibodies

AB272726

Anti-VIP antibody [EPR23288-43]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [EPR23288-43] (AB272726)

5
1

Primary Antibodies

AB227603

Anti-VIP antibody - C-terminal

Immunohistochemistry (Frozen sections) - Anti-VIP antibody - C-terminal (AB227603)

0
0

Primary Antibodies

AB227850

Anti-VIP antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody - C-terminal (AB227850)

0
0

Primary Antibodies

AB30680

Anti-VIP antibody [02]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)

0
0

Primary Antibodies

AB124788

Anti-VIP antibody [EPR4203]

20ul selling size|RabMAb|Recombinant

ELISA - Anti-VIP antibody [EPR4203] (AB124788)

0
0

組合せ製品

Primary Antibodies

AB108456

Anti-Somatostatin antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

5
5

Primary Antibodies

AB108986

Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (AB108986)

5
12

Primary Antibodies

AB283568

Anti-CGRP-I+CGRP-II antibody [EPR23804-95]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CGRP-I+CGRP-II antibody [EPR23804-95] (AB283568)

0
0

Primary Antibodies

AB181086

Anti-Parvalbumin antibody [EPR13091]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parvalbumin antibody [EPR13091] (AB181086)

5
5

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Reactivity data

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製品の詳細

This antibody detects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

After solid-phase absorption this antibody is filtered through a 0.22 µm filter, vialed and lyophilized.

バッファー組成

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Vasoactive Intestinal Peptide (VIP) also known as VIP or Alexa VIP is a 28-amino acid neuropeptide with a molecular mass of approximately 3326 Da. VIP is broadly expressed in both the central and peripheral nervous systems. It plays a mechanical role as a neurotransmitter and neuromodulator impacting various physiological functions such as vasodilation regulation of prolactin secretion and modulation of intestinal motility. By engaging in these processes VIP affects multiple bodily systems and acts at many sites within the human body.

Biological function summary

This protein influences immune response smooth muscle activity and circadian rhythm. VIP operates independently and as part of a complex in the body interacting with specific receptor types on the cellular surface like VPAC1 and VPAC2 receptors which are part of the G-protein coupled receptors family. VIP’s role as a regulator of immune response includes modulation of cytokine production and influencing lymphocyte activity implicating it as a significant player in homeostasis.

Pathways

A well-known function of VIP involves its participation in the cAMP signaling pathway which contributes to various cellular responses like neurotransmitter release and neuropeptide-mediated pathways influencing endocrine systems. VIP's activity in these pathways connects it to other proteins such as adenylate cyclase which it influences to increase cAMP levels further affecting processes such as synaptic transmission and the regulation of circadian rhythms. Through these pathways VIP affects physiological processes across the nervous and endocrine systems coordinating different aspects of bodily function.

VIP has notable associations with conditions such as inflammatory bowel disease (IBD) and asthma. The modulation of inflammatory processes by VIP impacts these diseases by influencing immune responses which can either exacerbate or alleviate symptoms. In IBD VIP interacts with elements of the immune system reducing inflammation and helping maintain mucosal integrity. In asthma VIP can alter airway inflammation and smooth muscle contraction through its pathways connected to the immune system and smooth muscle tissues interacting with proteins like cytokines that play roles in these conditions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Vasoactive intestinal peptide. VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors : VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed : 1318039, PubMed : 36385145, PubMed : 8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed : 3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed : 15013843).. Intestinal peptide PHM-27. Bioactive forms that cause vasodilation (PubMed : 15013843, PubMed : 3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed : 15013843).. Intestinal peptide PHV-42. Bioactive forms that cause vasodilation (PubMed : 15013843, PubMed : 3654650).

See full target information VIP

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文献 (20)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 16:1540465 PubMed40177363

2025

Aging-related impairment of neurogenic chloride secretion in human colon mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiyun Wang,Jing He,Pengcheng Yang,Tao Bai,Jun Song,Xiaohua Hou,Lei Zhang

Cellular and molecular gastroenterology and hepatology 19:101439 PubMed39667579

2024

Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Zhou,Min Yan,Qin Luo,Wen Qiu,Yu-Ru Guo,Xiao-Qing Guo,Hong-Bin Yu,Jing-Ru Huo,Yan-Lin Feng,De-Ping Wang,Teng Sun,Kai-Fang Wang,Jian-Yun Shi,Xuan Shang,Mei-Na Wu,Lin Wang,Ji-Min Cao

Frontiers in microbiology 15:1327630 PubMed38601933

2024

Electroacupuncture regulates gut microbiota to reduce depressive-like behavior in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Junying Wang,Haohan Zhu,Xingke Song,Jun Zhao,Jianliang Zhang,Jinling Zhang,Shaoyuan Li,Peijing Rong

The European journal of neuroscience 59:1993-2015 PubMed38382910

2024

Microglia cells treated with synthetic vasoactive intestinal peptide or transduced with LentiVIP protect neuronal cells against degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Azize Yasemin Goksu,Fatma Gonca Kocanci,Ersin Akinci,Devrim Demir-Dora,Fulya Erendor,Salih Sanlioglu,Hilmi Uysal

Cells 12: PubMed37681909

2023

Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis.

Applications

Unspecified application

Species

Unspecified reactive species

Peter W West,Chiara Tontini,Haris Atmoko,Orsolya Kiss,Terence Garner,Rajia Bahri,Richard B Warren,Christopher E M Griffiths,Adam Stevens,Silvia Bulfone-Paus

Nature neuroscience 26:820-829 PubMed37024573

2023

Prefrontal engrams of long-term fear memory perpetuate pain perception.

Applications

Unspecified application

Species

Unspecified reactive species

Alina Stegemann,Sheng Liu,Oscar Andrés Retana Romero,Manfred Josef Oswald,Yechao Han,Carlo Antonio Beretta,Zheng Gan,Linette Liqi Tan,William Wisden,Johannes Gräff,Rohini Kuner

Journal of digestive diseases 21:711-723 PubMed33405317

2020

Role of free radical scavenging activity of vasoactive intestinal peptide in the attenuation of mitochondrial dysfunction to ameliorate dextran sulphate sodium-induced colitis in mice: Implications in ulcerative colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Bengaluru Chandraiah Spoorthi,Sunil S More,Santhekadur Annappa Gautham,Shashwati Ghosh,Ishita Saha,Arpan Kumar Maiti

Gene therapy 28:130-141 PubMed32733091

2020

Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Fulya Erendor,Elif Ozgecan Sahin,Ahter D Sanlioglu,Mustafa Kemal Balci,Thomas S Griffith,Salih Sanlioglu

Oncogenesis 9:38 PubMed32205838

2020

Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chieh-Yang Cheng,Zongxiang Zhou,Meredith Stone,Bao Lu,Andrea Flesken-Nikitin,David M Nanus,Alexander Yu Nikitin

Reproduction (Cambridge, England) 157:475-484 PubMed30817320

2019

VIP activates primordial follicles of rat through ERK-mTOR pathway in tissue culture.

Applications

Unspecified application

Species

Unspecified reactive species

Song Li,Qi Fan,Yanqiu Xie,Haiyan Lin,Qi Qiu,Yihua Liang,Qingxue Zhang

View all publications

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