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AB272245

violetFluor™ 500 Anti-MHC Class II I Ab + Ad 抗体 [M5/114.15.2]

violetFluor™ 500 Anti-MHC Class II I Ab + Ad antibody [M5/114.15.2]

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Rat Monoclonal HB2Q antibody - conjugated to violetFluor™ 500. Suitable for Flow Cyt and reacts with Mouse samples.

別名を表示する

H2-Ab1

1 Images
Flow Cytometry - violetFluor™ 500 Anti-MHC Class II I Ab + Ad antibody [M5/114.15.2] (AB272245)
  • Flow Cyt

Supplier Data

Flow Cytometry - violetFluor™ 500 Anti-MHC Class II I Ab + Ad antibody [M5/114.15.2] (AB272245)

C57Bl/6 splenocytes were stained with APC Anti-Mouse CD3 and 0.25 ug ab272245 (right panel) or 0.25 ug violetFluor™ 500 Rat IgG2b isotype control (left panel).

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

M5/114.15.2

アイソタイプ

IgG2b

軽鎖のタイプ

kappa

標識

violetFluor™ 500

励起波長/蛍光波長
キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt

applications

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use at 0.25 μg per test.</p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
精製に関する特記事項
Purified from tissue culture supernatant.
バッファー組成
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MHC Class II I Ab + Ad often referred to simply as MHC II comprises heterodimeric molecules around 65 to 68 kDa expressed predominantly on antigen-presenting cells like dendritic cells macrophages and B cells. These molecules play an important mechanical role in the immune system by presenting peptides derived from extracellular proteins to CD4+ T helper cells. This antigen presentation starts the immune response process enabling the immune system to recognize and respond to pathogens effectively.
Biological function summary

MHC Class II molecules contribute significantly to the adaptive immune response forming part of the peptide-MHC complex. This complex presents processed antigen fragments to T cells. When T cell receptors on CD4+ T cells recognize and bind to these peptide-MHC complexes it triggers signaling cascades that result in T cell activation proliferation and differentiation. The I Ab + Ad refers to specific alleles in different strains of mice models critical for experimental studies in immunology.

Pathways

MHC Class II molecules play an important role in the antigen processing and presentation pathway an essential mechanism for adaptive immune responses. Additionally they participate in the toll-like receptor signaling pathway that helps recognize pathogen-associated molecular patterns. The pathway interactions involve other key proteins like CD4 which is a co-receptor that works alongside T cell receptors to enhance antigen recognition and signaling during immune responses.

MHC Class II molecules have strong associations with autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. Alterations or mutations within MHC class II can disrupt normal immune functioning leading to self-antigen recognition. These abnormalities often relate to proteins like TNF-α which work in inflammatory pathways and enhance the autoimmunity in these disorders. Understanding these connections improves insights into disease mechanisms and aids in developing therapeutic interventions.

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

ターゲットの情報

See full target information H2-Ab1

追加のターゲット

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