Anti-VEGF Receptor 3 抗体 (ab10284)
Key features and details
- Rabbit polyclonal to VEGF Receptor 3
- Suitable for: WB, ELISA, Flow Cyt, IHC-Fr, IP, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-VEGF Receptor 3 antibody
VEGF Receptor 3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to VEGF Receptor 3 -
由来種
Rabbit -
特異性
In Western blots, this antibody shows a moderate cross-reactivity with VEGFR2/KDR and a weak cross-reactivity with VEGFR1/FLT1. -
アプリケーション
適用あり: WB, ELISA, Flow Cyt, IHC-Fr, IP, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment (His-tag) corresponding to Human VEGF Receptor 3 aa 1-800.
Database link: P35916 -
ポジティブ･コントロール
- IHC-Fr: Human spleen tissue. ICC/IF: MG63 cells. Flow Cyt: HDLEC.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab10284の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
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| ELISA |
Use at an assay dependent concentration.
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| Flow Cyt |
Use a concentration of 1 - 5 µg/ml.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
|
| IHC-Fr | (1) |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration. PubMed: 19366703
|
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| ICC/IF |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
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WB
Use at an assay dependent concentration. |
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ELISA
Use at an assay dependent concentration. |
|
Flow Cyt
Use a concentration of 1 - 5 µg/ml. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
|
IHC-Fr
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. PubMed: 19366703 |
|
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Receptor for VEGFC. Has a tyrosine-protein kinase activity. -
組織特異性
Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. -
関連疾患
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2324 Human
- Omim: 136352 Human
- SwissProt: P35916 Human
- Unigene: 646917 Human
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別名
- EC 2.7.10.1 antibody
- flt 4 antibody
- FLT-4 antibody
see all
画像
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Immunohistochemistry (Frozen sections) - Anti-VEGF Receptor 3 antibody (ab10284)
Immunohistochemistry (Frozen sections) analysis of human spleen tissue labelling VEGF Receptor 3 with ab10284.
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Immunocytochemistry/ Immunofluorescence - Anti-VEGF Receptor 3 antibody (ab10284)Immunocytochemistry/Immunofluorescence analysis of human VEGF Receptor 3 transfected MG63 cells labelling VEGF Receptor 3 (red) with ab10284 (D). A and C are negative controls with secondary antibody only. B uses a monoclonal antibody specific for VEGF Receptor 3.
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Flow Cytometry - Anti-VEGF Receptor 3 antibody (ab10284)Flow Cytometry analysis of human dermal lymphatic endothelial cells (HDLEC) labelling VEGF Receptor 3 with ab10284.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab10284 は 3 報の論文で使用されています。
- Liu X et al. Efficacy of puerarin in rats with focal cerebral ischemia through modulation of the SIRT1/HIF-1α/VEGF signaling pathway and its effect on synaptic plasticity. Heliyon 9:e15872 (2023). PubMed: 37223716
- Yu DS et al. Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements. Front Microbiol 9:2724 (2018). PubMed: 30483236
- Toivanen PI et al. Novel vascular endothelial growth factor D variants with increased biological activity. J Biol Chem 284:16037-48 (2009). IP ; Pig . PubMed: 19366703
