AB231670

Anti-VE-PTP 抗体

Name: Anti-VE-PTP 抗体 (ab231670) | Abcam
Brand: Abcam Limited
SKU: AB231670
Price: 74000 JPY
Availability: InStock

Anti-VE-PTP antibody

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(1 Publication)

Rabbit Polyclonal protein-tyrosine-phosphatase antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication.

別名を表示する

Ptprb

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat liver tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat skeletal muscle tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat heart tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat brain tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat spinal cord tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-VE-PTP antibody (AB231670)

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Western blot - Anti-VE-PTP antibody (ab231670) at 2 µg/mL

All lanes:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 224 kDa

false

Supplier Data

Western blot - Anti-VE-PTP antibody (AB231670)

All lanes:

Western blot - Anti-VE-PTP antibody (ab231670) at 2 µg/mL

All lanes:

Recombiant rat VE-PTP protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 224 kDa,42 kDa,57 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat

アプリケーション

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab231670 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

VE-PTP also known as vascular endothelial protein tyrosine phosphatase is an enzyme with a mass of approximately 300 kDa. This protein is part of the receptor-type protein tyrosine phosphatase family and it mainly localizes at endothelial cell junctions. VE-PTP plays an important role in maintaining endothelial cell permeability by dephosphorylating specific tyrosine residues on target proteins such as the VE-cadherin complex. Its expression confines mostly to vascular endothelial cells where it is involved in processes affecting vascular stability and signaling.

Biological function summary

The function of this protein extends to its involvement in the modulation of cell adhesion through its interaction with adherens junctions complexes. VE-PTP associates with complexes like VE-cadherin and plakoglobin to regulate cell–cell junctions influencing the integrity and permeability of the vascular endothelium. This activity is important in processes such as angiogenesis and the maintenance of vascular barrier function making it a significant player in vascular biology.

Pathways

The participation of VE-PTP is notably within the angiogenesis and vascular barrier regulation pathways. The protein governs these pathways by regulating signals through interactions with proteins like VE-cadherin and VEGFR2 which are essential in vascular development and response to growth factors. Its phosphatase activity moderates the phosphorylation state of these key partners thereby influencing the downstream signaling events vital for endothelial function and vascular homeostasis.

The function of VE-PTP associates with pathological conditions such as cancer and cardiovascular diseases. In cancer its role in angiogenesis can contribute to tumor vascularization impacting tumor growth and metastasis. Meanwhile in cardiovascular diseases its influence on endothelial permeability can affect atherosclerotic plaque stability and contribute to vascular complications. Interacting proteins such as VEGFR2 are also implicated in these disorders linking VE-PTP to these disease pathways through their regulatory relationships in endothelial dynamics.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information protein-tyrosine-phosphatase

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 3:1202-1216 PubMed34552271

2021

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Aliluev,Sophie Tritschler,Michael Sterr,Lena Oppenländer,Julia Hinterdobler,Tobias Greisle,Martin Irmler,Johannes Beckers,Na Sun,Axel Walch,Kerstin Stemmer,Alida Kindt,Jan Krumsiek,Matthias H Tschöp,Malte D Luecken,Fabian J Theis,Heiko Lickert,Anika Böttcher

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-VE-PTP 抗体

Anti-VE-PTP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Western blot - Anti-VE-PTP antibody (AB231670)

Western blot - Anti-VE-PTP antibody (AB231670)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

Abcam product promise