Anti-VE-PTP 抗体 [122.2] (ab31654)
Key features and details
- Mouse monoclonal [122.2] to VE-PTP
- Suitable for: ICC, IP, ICC/IF, WB
- Reacts with: Rat
- Isotype: IgM
製品の概要
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製品名
Anti-VE-PTP antibody [122.2]
VE-PTP 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [122.2] to VE-PTP -
由来種
Mouse -
特異性
This antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan). -
アプリケーション
適用あり: ICC, IP, ICC/IF, WBmore details -
種交差性
交差種: Rat -
免疫原
Tissue, cells or virus corresponding to Rat VE-PTP. (Embryonic rat brain proteoglycans).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Constituent: PBS -
Concentration information loading... -
特記事項（精製）
Concentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS. -
ポリ/モノ
モノクローナル -
クローン名
122.2 -
アイソタイプ
IgM -
研究分野
関連製品
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Compatible Secondaries
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab31654の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
ICC
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. -
配列類似性
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Contains 17 fibronectin type-III domains.
Contains 1 tyrosine-protein phosphatase domain. -
細胞内局在
Membrane. - Information by UniProt
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別名
- HPTP BETA antibody
- HPTPB antibody
- Phosphacan receptor type B antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (1)
ab31654 は 1 報の論文で使用されています。
- Ou M et al. HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm. ESC Heart Fail 9:2955-2966 (2022). PubMed: 35730141
