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AB31654

Anti-VE-PTP 抗体 [122.2]

Anti-VE-PTP antibody [122.2]

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(2 Publications)

Mouse Monoclonal VE-PTP antibody. Suitable for ICC, IP, WB, ICC/IF and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Tissue preparation containing VE-PTP protein.

別名を表示する

HPTP BETA, HPTPB, PTPB, PTPRB_HUMAN, Phosphacan receptor type B, Protein tyrosine phosphatase receptor type B, Protein-tyrosine phosphatase beta, R-PTP-beta, RPTPB, Receptor-type tyrosine-protein phosphatase beta, VE-PTP, Vascular endothelial protein tyrosine phosphatase

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

122.2

アイソタイプ

IgM

キャリアフリー

No

交差種

Rat

アプリケーション

ICC, ICC/IF, WB, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

This antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製に関する特記事項
Concentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS.
バッファー組成
Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

VE-PTP also known as vascular endothelial protein tyrosine phosphatase is an enzyme with a mass of approximately 300 kDa. This protein is part of the receptor-type protein tyrosine phosphatase family and it mainly localizes at endothelial cell junctions. VE-PTP plays an important role in maintaining endothelial cell permeability by dephosphorylating specific tyrosine residues on target proteins such as the VE-cadherin complex. Its expression confines mostly to vascular endothelial cells where it is involved in processes affecting vascular stability and signaling.
Biological function summary

The function of this protein extends to its involvement in the modulation of cell adhesion through its interaction with adherens junctions complexes. VE-PTP associates with complexes like VE-cadherin and plakoglobin to regulate cell–cell junctions influencing the integrity and permeability of the vascular endothelium. This activity is important in processes such as angiogenesis and the maintenance of vascular barrier function making it a significant player in vascular biology.

Pathways

The participation of VE-PTP is notably within the angiogenesis and vascular barrier regulation pathways. The protein governs these pathways by regulating signals through interactions with proteins like VE-cadherin and VEGFR2 which are essential in vascular development and response to growth factors. Its phosphatase activity moderates the phosphorylation state of these key partners thereby influencing the downstream signaling events vital for endothelial function and vascular homeostasis.

The function of VE-PTP associates with pathological conditions such as cancer and cardiovascular diseases. In cancer its role in angiogenesis can contribute to tumor vascularization impacting tumor growth and metastasis. Meanwhile in cardiovascular diseases its influence on endothelial permeability can affect atherosclerotic plaque stability and contribute to vascular complications. Interacting proteins such as VEGFR2 are also implicated in these disorders linking VE-PTP to these disease pathways through their regulatory relationships in endothelial dynamics.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information VE-PTP
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

ESC heart failure 9:2955-2966 PubMed35730141

2022

HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm.

Applications

Unspecified application

Species

Unspecified reactive species

Minghui Ou,Yaonan Chu,Qian Zhang,Huidong Zhao,Qiang Song

Cell 131:861-72 PubMed18035408

2007

Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Applications

Unspecified application

Species

Unspecified reactive species

Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka
View all publications
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代替製品

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AB229661

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