Anti-VDAC2 抗体 (ab37985)
Key features and details
- Goat polyclonal to VDAC2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-VDAC2 antibody
VDAC2 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to VDAC2 -
由来種
Goat -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rabbit, Cow, Dog, Pig
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免疫原
Synthetic peptide corresponding to Human VDAC2 aa 250 to the C-terminus (C terminal).
Database link: P45880 -
ポジティブ･コントロール
- WB: Human cerebellum cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab37985の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (7) |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa).
1 hour primary incubation is recommended for this product. |
| 特記事項 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa). 1 hour primary incubation is recommended for this product. |
ターゲット情報
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機能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. -
組織特異性
Expressed in all tissues examined. -
配列類似性
Belongs to the eukaryotic mitochondrial porin family. -
ドメイン
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. -
細胞内局在
Mitochondrion outer membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 282120 Cow
- Entrez Gene: 479255 Dog
- Entrez Gene: 7417 Human
- Entrez Gene: 397659 Pig
- Omim: 193245 Human
- SwissProt: P45880 Human
- SwissProt: Q9MZ15 Pig
- Unigene: 355927 Human
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別名
- B-36 vdac antibody
- FLJ23841 antibody
- hVDAC2 antibody
see all
画像
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Western blot - Anti-VDAC2 antibody (ab37985)Anti-VDAC2 antibody (ab37985) at 1 µg/ml + Human Cerebellum lysate in RIPA buffer at 35 µg
Predicted band size: 32 kDaDetected by chemiluminescence.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (22)
ab37985 は 22 報の論文で使用されています。
- Battaglia AM et al. Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions. Front Cell Dev Biol 11:1272667 (2023). PubMed: 38033861
- Battaglia AM et al. Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells. Front Oncol 12:868351 (2022). PubMed: 35433479
- Reina S et al. Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress. Redox Biol 51:102264 (2022). PubMed: 35180474
- Singulani MP et al. Impairment of PGC-1a-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease. Exp Gerontol 133:110882 (2020). PubMed: 32084533
- Li D et al. Quercetin Alleviates Ferroptosis of Pancreatic ß Cells in Type 2 Diabetes. Nutrients 12:N/A (2020). PubMed: 32992479