Anti-VDAC2 抗体 (ab118872)
Key features and details
- Goat polyclonal to VDAC2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-VDAC2 antibody
VDAC2 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to VDAC2 -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Dog, Pig
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免疫原
Synthetic peptide within Human VDAC2 aa 250 to the C-terminus (C terminal) (Cysteine residue). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P45880-1 -
ポジティブ･コントロール
- Human testis lysate, Human heart tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 98% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab118872の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32 kDa.
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| IHC-P |
Use a concentration of 2.5 - 5 µg/ml.
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| 特記事項 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32 kDa. |
|
IHC-P
Use a concentration of 2.5 - 5 µg/ml. |
ターゲット情報
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機能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. -
組織特異性
Expressed in all tissues examined. -
配列類似性
Belongs to the eukaryotic mitochondrial porin family. -
ドメイン
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. -
細胞内局在
Mitochondrion outer membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 282120 Cow
- Entrez Gene: 479255 Dog
- Entrez Gene: 7417 Human
- Entrez Gene: 22334 Mouse
- Entrez Gene: 397659 Pig
- Entrez Gene: 83531 Rat
- Omim: 193245 Human
- SwissProt: P45880 Human
see all -
別名
- B-36 vdac antibody
- FLJ23841 antibody
- hVDAC2 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VDAC2 antibody (ab118872)Immunohistochemical staining of ab118872 at 5 µg/ml staining VDAC2 in Paraffin-embedded Human heart tissue followed by biotinylated anti-Goat IgG secondary antibody, alkaline phosphatasestreptavidin and chromogen
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Western blot - Anti-VDAC2 antibody (ab118872)Anti-VDAC2 antibody (ab118872) at 0.3 µg/ml + Human testis lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 32 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab118872 は 2 報の論文で使用されています。
- Triplett JC et al. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta 1852:2213-24 (2015). PubMed: 26248058
- Tanno M et al. Translocation of glycogen synthase kinase-3ß (GSK-3ß), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). J Biol Chem 289:29285-96 (2014). PubMed: 25187518