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AB109544

Anti-VAV3 (phospho Y173) 抗体 [EPR1068A]

Anti-VAV3 (phospho Y173) antibody [EPR1068A]

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(3 Publications)

Rabbit Recombinant Monoclonal VAV3 phospho Y173 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

別名を表示する

Guanine nucleotide exchange factor VAV3, VAV-3, VAV3

1 Images
Western blot - Anti-VAV3 (phospho Y173) antibody [EPR1068A] (AB109544)
  • WB

Unknown

Western blot - Anti-VAV3 (phospho Y173) antibody [EPR1068A] (AB109544)

All lanes:

Western blot - Anti-VAV3 (phospho Y173) antibody [EPR1068A] (ab109544) at 1/1000 dilution

Lane 1:

Jurkat cell lysate at 10 µg

Lane 2:

Jurkat cell lysate treated with Pervanadate at 10 µg

Predicted band size: 98 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-VAV3 (phospho Y173) antibody [EPR1068A] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR1068A

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The VAV3 protein also known as the guanine nucleotide exchange factor VAV3 functions as a regulator of Rho family GTPases by promoting the exchange of GDP for GTP. It weighs approximately 101 kDa and exhibits expression in various tissues including the brain heart and hematopoietic cells. VAV3 serves as an important modulator within the intracellular signaling processes by influencing actin cytoskeletal dynamics and impacting cellular morphology and movement.
Biological function summary

VAV3 influences multiple cellular processes like cell proliferation differentiation and migration. Part of many signaling complexes VAV3 interacts with receptors on the cell surface transmitting signals inside the cell. These interactions play a role in the regulation of immune responses and its involvement in the nervous system aids in neuron development and connectivity.

Pathways

VAV3 takes part in the regulation of the Rho GTPase pathway and the phosphoinositide 3-kinase (PI3K) pathway. VAV3 cooperates with proteins such as RAC1 and CDC42 influencing these pathways to modulate cell survival cytoskeleton rearrangement and membrane trafficking. Interaction with PI3K pathway components amplifies signals for growth factor-induced cellular responses impacting the overall cell function and homeostasis.

VAV3 influences both cancer and autoimmune diseases due to its regulatory role in cell signaling. Overexpression or abnormal regulation of VAV3 relates to prostate cancer progression and metastasis through its interaction with androgen receptor signaling pathways. In autoimmune diseases VAV3's interaction with proteins such as SYK can affect the severity of conditions like rheumatoid arthritis by modulating immune cell activation and response.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
See full target information Guanine nucleotide exchange factor VAV3 phospho Y173
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:3056 PubMed35650206

2022

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

R C Nayak,K H Chang,A K Singh,M Kotliar,M Desai,A M Wellendorf,M Wunderlich,J Bartram,B Mizukawa,M Cuadrado,P Dexheimer,A Barski,X R Bustelo,N N Nassar,J A Cancelas

The Journal of biological chemistry 291:23854-23868 PubMed27681594

2016

Bone-protective Functions of Netrin 1 Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Kenta Maruyama,Takahiko Kawasaki,Masahide Hamaguchi,Motomu Hashimoto,Moritoshi Furu,Hiromu Ito,Takao Fujii,Naoki Takemura,Thangaraj Karuppuchamy,Takeshi Kondo,Takumi Kawasaki,Masahiro Fukasaka,Takuma Misawa,Tatsuya Saitoh,Yutaka Suzuki,Mikaël M Martino,Yutaro Kumagai,Shizuo Akira

Molecular cancer research : MCR 11:1235-47 PubMed23938949

2013

Downregulation of HOPX controls metastatic behavior in sarcoma cells and identifies genes associated with metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Denisa Kovárová,Jirí Plachy,Jan Kosla,Katerina Trejbalová,Vladimír Čermák,Jiří Hejnar
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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