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AB181684

Anti-VANGL2 抗体 - N-terminal

Anti-VANGL2 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal VANGL2 antibody. N-terminal. Suitable for ICC, ELISA, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human VANGL2.

別名を表示する

KIAA1215, STB1, VANGL2, Vang-like protein 2, Loop-tail protein 1 homolog, Strabismus 1, Van Gogh-like protein 2

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC, ELISA

applications

免疫原

Synthetic Peptide within Human VANGL2. The exact immunogen used to generate this antibody is proprietary information.

Q9ULK5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

VANGL2 also called Van Gogh-like protein 2 is a transmembrane protein involved in the planar cell polarity (PCP) pathway. It has a mass of approximately 60 kDa. This protein is expressed in various tissues including the brain heart and kidneys. In terms of mechanical function VANGL2 acts at the cell membrane to regulate cellular orientation and movement playing a central role in processes where cells need to align in a uniform direction.
Biological function summary

VANGL2 interacts with several other proteins to form the PCP complex. This complex controls the orientation of cells within the plane of a tissue. VANGL2 regulates cytoskeletal dynamics and affects cell signaling influencing important cellular processes like migration and intercellular communication. Moreover its presence is essential for the proper development and functioning of various organ systems including the neural tube and cardiac outflow tract.

Pathways

VANGL2 appears in the PCP signaling and Wnt signaling pathways. These pathways are critical in shaping tissue architecture during embryonic development. In the PCP pathway VANGL2 interacts with proteins such as Dishevelled and Prickle. In the Wnt signaling pathway VANGL2 plays a part in forwarding signals that control cell fate decisions and proliferation connecting to proteins like Frizzled and Beta-catenin.

VANGL2 has strong ties to conditions such as neural tube defects and congenital heart disease. Mutations in VANGL2 can disrupt normal developmental processes leading to these disorders. The protein interacts with SCRIB in the context of neural tube defects where misregulation can result in conditions like spina bifida. Similarly VANGL2 mutations interfere with NOTCH signaling a pathway linked to congenital heart disease illustrating its significant role in maintaining cardiovascular health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).
See full target information VANGL2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of endocrinology 250:93-104 PubMed34101614

2021

Disruption of endothelial Pfkfb3 ameliorates diet-induced murine insulin resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuhua Yang,Jiean Xu,Qian Ma,Zhiping Liu,Yaqi Zhou,Yongfeng Cai,Xiaoxiao Mao,David Stepp,Neal Weintraub,David J Fulton,Mei Hong,Yuqing Huo
View all publications
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代替製品

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Primary Antibodies

AB198887

Anti-VANGL2 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VANGL2 antibody - N-terminal (AB198887)

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組合せ製品

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Primary Antibodies

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Secondary Antibodies

AB150077

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Primary Antibodies

AB198745

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