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AB188239

Anti-USP26 抗体

Anti-USP26 antibody

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(1 Publication)

Rabbit Polyclonal USP26 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP26 aa 500-800.

別名を表示する

Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26, USP26

2 Images
Western blot - Anti-USP26 antibody (AB188239)
  • WB

Supplier Data

Western blot - Anti-USP26 antibody (AB188239)

Western blot analysis (using ab188239 at a 1/2000 dilution) of immunoprecipitates using 293T cell extracts transfected or not with Flag-USP26

Lane 1 : Input of non-transfected 293 cells

Lane 2 : Input of transfected cells with Flag-USP26

Lane 3 : immunoprecipitate with control serum+protein A sepharose.

Lane 4 : immunoprecipitate with ab188239+ protein A sepharose.

All lanes:

Western blot - Anti-USP26 antibody (ab188239)

Predicted band size: 104 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)

Immunofluorescent analysis of 3% PFA-fixed U2OS cells overexpressing DDDDK-tagged USP26, labeling USP26 (red) with ab188239 at 1/5000 dilution. Cells were also stained with an Anti-DDDDK tag antibody (green).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human USP26 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.

Q9BXU7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Preservative: 0.05% Sodium azide
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

USP26 also known as Ubiquitin Specific Peptidase 26 is an enzyme that removes ubiquitin moieties from specific proteins regulating their degradation localization or activity. USP26 is part of the deubiquitinating enzymes (DUBs) family and has a molecular mass of approximately 104 kDa. It expresses mainly in testicular tissue which indicates its role in reproductive biology.
Biological function summary

The enzyme plays a role in spermatogenesis the process of sperm cell development. It participates in the regulation of the androgen receptor (AR) signaling pathway. By interacting with receptors it stabilizes and modulates their activity contributing to normal testicular function. This connects USP26 to a protein complex involving androgen receptors which are essential for male reproductive health.

Pathways

The deubiquitinating activity of USP26 influences the androgen receptor signaling pathway important for male reproductive processes. In the ubiquitin-proteasome system USP26 modulates the stability of the AR receptor and other proteins related to this pathway which may include factors like HSP90 that aid in receptor activation and stabilization.

Anomalies in USP26 function correlate with male infertility. Mutations or altered expression are linked to disorders in spermatogenesis. This has connections with androgen receptor abnormalities as proper receptor function is necessary for normal sperm production. Studies also find indications that dysregulation may link to prostate cancer where androgen receptor involvement is critical.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed : 20501646, PubMed : 28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed : 28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed : 20501646). May play a role in spermatogenesis (PubMed : 34202084).
See full target information USP26
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 448:52-60 PubMed30763716

2019

USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Li,Honghong Zhou,Rui Zhu,Zhihua Liu
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

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