Anti-USP2 抗体 (ab168945)
Key features and details
- Mouse polyclonal to USP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-USP2 antibody
USP2 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to USP2 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow
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免疫原
Recombinant full length protein corresponding to amino acids 1-605 of Human USP2 (AAH02955.1)
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ポジティブ･コントロール
- USP2 transfected 293T cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.4
Constituent: 99% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab168945の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa.
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| 特記事項 |
|---|
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa. |
ターゲット情報
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機能
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. -
組織特異性
Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). -
配列類似性
Belongs to the peptidase C19 family. USP2 subfamily. -
ドメイン
The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity. -
細胞内局在
Nucleus and Cytoplasm. Cytoplasm > perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 9099 Human
- Entrez Gene: 53376 Mouse
- Entrez Gene: 115771 Rat
- Omim: 604725 Human
- SwissProt: O75604 Human
- SwissProt: O88623 Mouse
- SwissProt: Q5U349 Rat
- Unigene: 524085 Human
see all -
別名
- 41 kDa ubiquitin specific protease antibody
- 41 kDa ubiquitin-specific protease antibody
- Deubiquitinating enzyme 2 antibody
see all
画像
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Western blot - Anti-USP2 antibody (ab168945)All lanes : Anti-USP2 antibody (ab168945) at 1 µg/ml
Lane 1 : USP2 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
Secondary
All lanes : Goat anti-mouse IgG at 1/2500 dilution
Predicted band size: 68 kDa
データシートおよび資料
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Datasheet download
参考文献 (0)
ab168945 は論文での使用が確認できていません。
