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AB82714

Anti-USH2A 抗体

Anti-USH2A antibody

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Rabbit Polyclonal USH2A antibody. Suitable for ELISA and reacts with Human samples.

別名を表示する

Usherin, Usher syndrome type IIa protein, Usher syndrome type-2A protein, USH2A

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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製品の詳細

We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 24/11/2017. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

USH2A also known as Usherin is a protein encoded by the USH2A gene. This protein has a mass of approximately 610 kDa. It is a large transmembrane protein found mainly in the retina and the inner ear. USH2A contains several modules including laminin EGF-like fibronectin type III and laminin G domains which contribute to its role in cellular adhesion and signal transduction. The protein localizes on the photoreceptor cells in the eye and plays a role in maintaining their structure.
Biological function summary

USH2A supports the structural integrity and function of photoreceptors and hair cells. It is not part of a known complex but interacts closely with other proteins in the extracellular matrix. The protein helps stabilize the connections between cells by interacting with cell-surface receptors. This interaction supports proper sensory perception by maintaining cell ellipsoid zones in the retina and stereocilia in the ear.

Pathways

The protein interacts within the Usher syndrome pathway and the visual cycle pathway. In these pathways it is closely related to other Usher syndrome-associated proteins such as ADGRV1 and WHRN. These proteins form networks that are essential for the maintenance of photoreceptor cells and sensory hair cells. USH2A contributes to the complex processes that are necessary for both vision and hearing.

USH2A mutations are linked to Usher syndrome type II and retinitis pigmentosa. Usher syndrome type II leads to moderate hearing loss and progressive vision loss while retinitis pigmentosa results in the degeneration of the retina. In these disorders other proteins such as MYO7A and CDH23 are also implicated but USH2A mutations have been identified as significant contributors especially to the degradation and dysfunction of sensory cells in the affected tissues.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
See full target information USH2A
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