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AB157476

Anti-UGT1A6 抗体 [EPR11068]

Anti-UGT1A6 antibody [EPR11068]

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(5 Publications)

Rabbit Recombinant Monoclonal UGT1A6 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.

別名を表示する

GNT1, UGT1, UGT1A6, UDP-glucuronosyltransferase 1A6, Phenol-metabolizing UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1-6, UDP-glucuronosyltransferase 1-F, UDPGT 1-6, UGT1*6, UGT1-06, UGT1.6, UGT-1F, UGT1F

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT1A6 antibody [EPR11068] (AB157476)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT1A6 antibody [EPR11068] (AB157476)

Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling UGT1A6 with ab157476 at 1/250 dilution.

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT1A6 antibody [EPR11068] (AB157476)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT1A6 antibody [EPR11068] (AB157476)

Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling UGT1A6 with ab157476 at 1/250 dilution.

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-UGT1A6 antibody [EPR11068] (AB157476)
  • WB

Unknown

Western blot - Anti-UGT1A6 antibody [EPR11068] (AB157476)

All lanes:

Western blot - Anti-UGT1A6 antibody [EPR11068] (ab157476) at 1/1000 dilution

Lane 1:

Caco-2 cell lysate at 10 µg

Lane 2:

Fetal liver tissue lysate at 10 µg

Lane 3:

A431 cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 61 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-UGT1A6 antibody [EPR11068] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR11068

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

UGT1A6 also known as UDP-glucuronosyltransferase 1A6 is an enzyme involved in the glucuronidation process which is critical for detoxifying and eliminating compounds from the body. This enzyme has a molecular mass of approximately 55 kDa. It is widely expressed in the liver as well as in the intestine and kidney where it catalyzes the transfer of glucuronic acid to various substrates. The enzyme achieves this by transforming small lipophilic molecules into more water-soluble forms for easier excretion.
Biological function summary

The UGT1A6 enzyme functions in the phase II metabolism of various endogenous and exogenous substrates contributing to the body's defense mechanism. It is part of the larger UGT1A gene complex which includes several other UGT enzymes that share exon regions highlighting their evolutionary versatility. UGT1A6 primarily catalyzes the conjugation of planar phenols such as acetaminophen and a variety of other phenolic and aromatic amines. Through these activities the enzyme plays an integral role in maintaining metabolic balance.

Pathways

UGT1A6 operates within detoxification and drug metabolism pathways including glucuronidation pathways for processing drugs and toxins. It interacts with cytochrome P450 enzymes which help in oxidative metabolism providing substrates for UGT1A6 to convert into more polar metabolites. The conjugative actions of UGT1A6 in these pathways facilitate efficient elimination of potentially harmful compounds and maintain metabolic homeostasis.

Mutations or altered expression of UGT1A6 can impact the body's drug-processing capabilities contributing to diseases such as Gilbert's syndrome and possible drug toxicity. In Gilbert's syndrome there is often a connection with UGT1A1 another UGT family enzyme leading to elevated levels of unconjugated bilirubin in the blood. UGT1A6's role in drug metabolism suggests that it may influence conditions related to drug sensitivity and resistance making it a significant factor in pharmacogenomics and personalized medicine approaches.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Isoform 1. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed : 15231852, PubMed : 21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed : 15231852, PubMed : 21422672). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (PubMed : 15231852). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (By similarity). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed : 21422672).. Isoform 3. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1.
See full target information UDP-glucuronosyltransferase 1-6
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Critical reviews in immunology 45:67-78 PubMed40921147

2025

Galectin-10 Silencing Reduces Eosinophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps by Inhibiting the p38/MAPK/NF-κB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chunhua Li,HongBing Liu

Biological & pharmaceutical bulletin 45:446-451 PubMed35370268

2022

The Effect of Single-Walled Carbon Nanotubes on UDP-Glucuronosyltransferase 1A Activity in Human Liver.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Asai,Masayuki Nadai,Miki Katoh

Cancer medicine 10:8673-8692 PubMed34617407

2021

Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Jin,Yuansheng Zheng,Zhencong Chen,Fei Wang,Guoshu Bi,Ming Li,Jiaqi Liang,Qihai Sui,Yunyi Bian,Zhengyang Hu,Yulei Qiao,Songtao Xu

Frontiers in pharmacology 12:660641 PubMed34040527

2021

Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Monivan Chhour,Pierre Perio,Regis Gayon,Hélène Ternet-Fontebasso,Gilles Ferry,Françoise Nepveu,Jean A Boutin,Jan Sudor,Karine Reybier

Pharmaceutics 12: PubMed33238436

2020

Differential Effects of 1α,25-Dihydroxyvitamin D on the Expressions and Functions of Hepatic CYP and UGT Enzymes and Its Pharmacokinetic Consequences In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Trang Nguyen Kieu Doan,Dang-Khoa Vo,Hyojung Kim,Anusha Balla,Yunjong Lee,In-Soo Yoon,Han-Joo Maeng
View all publications
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代替製品

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Abcam product promise

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